The effect of omitted covariates in marginal and partially conditional recurrent event analyses.
Cook, Richard J
Lifetime data analysis
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Zhong, Y., & Cook, R. J. (2019). The effect of omitted covariates in marginal and partially conditional recurrent event analyses.. Lifetime data analysis, 25 (2), 280-300. https://doi.org/10.1007/s10985-018-9430-y
There have been many advances in statistical methodology for the analysis of recurrent event data in recent years. Multiplicative semiparametric rate-based models are widely used in clinical trials, as are more general partially conditional rate-based models involving event-based stratification. The partially conditional model provides protection against extra-Poisson variation as well as event-dependent censoring, but conditioning on outcomes postrandomization can induce confounding and compromise causal inference. The purpose of this article is to examine the consequences of model misspecification in semiparametric marginal and partially conditional rate-based analysis through omission of prognostic variables. We do so using estimating function theory and empirical studies.
Humans, Recurrence, Data Interpretation, Statistical, Models, Statistical, Markov Chains, Sensitivity and Specificity, Biometry, Data Accuracy, Data Analysis
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External DOI: https://doi.org/10.1007/s10985-018-9430-y
This record's URL: https://www.repository.cam.ac.uk/handle/1810/277785
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/