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The effect of omitted covariates in marginal and partially conditional recurrent event analyses.


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Authors

Cook, Richard J 

Abstract

There have been many advances in statistical methodology for the analysis of recurrent event data in recent years. Multiplicative semiparametric rate-based models are widely used in clinical trials, as are more general partially conditional rate-based models involving event-based stratification. The partially conditional model provides protection against extra-Poisson variation as well as event-dependent censoring, but conditioning on outcomes post-randomization can induce confounding and compromise causal inference. The purpose of this article is to examine the consequences of model misspecification in semiparametric marginal and partially conditional rate-based analysis through omission of prognostic variables. We do so using estimating function theory and empirical studies.

Description

Keywords

Asymptotic bias, Confounding, Marginal, Partially conditional, Rate function, Recurrent events, Biometry, Data Accuracy, Data Analysis, Data Interpretation, Statistical, Humans, Markov Chains, Models, Statistical, Recurrence, Sensitivity and Specificity

Journal Title

Lifetime Data Anal

Conference Name

Journal ISSN

1380-7870
1572-9249

Volume Title

25

Publisher

Springer Science and Business Media LLC
Sponsorship
MRC (unknown)