Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses.
Genin, Guy M
Lu, Tian Jian
Physics of Life Reviews
MetadataShow full item record
Cheng, B., Lin, M., Huang, G., Li, Y., Ji, B., Genin, G. M., Deshpande, V., et al. (2017). Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses.. Physics of Life Reviews, 22-23 88-119. https://doi.org/10.1016/j.plrev.2017.06.016
Cells in vivo reside within complex microenvironments composed of both biochemical and biophysical cues. The dynamic feedback between cells and their microenvironments hinges upon biophysical cues that regulate critical cellular behaviors. Understanding this regulation from sensing to reaction to feedback is therefore critical, and a large effort is afoot to identify and mathematically model the fundamental mechanobiological mechanisms underlying this regulation. This review provides a critical perspective on recent progress in mathematical models for the responses of cells to the biophysical cues in their microenvironments, including dynamic strain, osmotic shock, fluid shear stress, mechanical force, matrix rigidity, porosity, and matrix shape. The review highlights key successes and failings of existing models, and discusses future opportunities and challenges in the field.
Biomechanics, Cellular mechanosensing, Focal adhesions, Mathematical modeling, Mechanobiology, Signaling pathway
This work was supported by the National Natural Science Foundation of China (11372243, 11522219, 11532009, 11402192), the Chinese Ministry of Education through a Changjiang Scholar award to GMG, the National Institutes of Health through grants U01EB016422 and R01HL109505, and the NSF Science and Technology Center for Engineering Mechanobiology, grant CMMI 1548571.
External DOI: https://doi.org/10.1016/j.plrev.2017.06.016
This record's URL: https://www.repository.cam.ac.uk/handle/1810/278010
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: http://creativecommons.org/licenses/by-nc-nd/4.0/