Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow.

Abstract

We report an acridium-based organic photocatalyst as an efficient replacement for iridium-based photocatalysts to single electron oxidise boronic acid derivatives. Furthermore, we applied the developed catalytic system to the synthesis of four active pharmaceutical ingredients (APIs). A straightforward scale up approach using continuous flow photoreactors is also reported affording gram an hour throughput.