Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow.
Rahman, Husaini BA
Chemical communications (Cambridge, England)
Royal Society of Chemistry (RSC)
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Lima, F., Grunenberg, L., Rahman, H. B., Labes, R., Sedelmeier, J., & Ley, S. (2018). Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow.. Chemical communications (Cambridge, England), 54 (44), 5606-5609. https://doi.org/10.1039/c8cc02169d
We report an acridium-based organic photocatalyst as an efficient replacement for iridium-based photocatalysts to single electron oxidise boronic acid derivatives. Furthermore, we applied the developed catalytic system to the synthesis of four active pharmaceutical ingredients (APIs). A straightforward scale up approach using continuous flow photoreactors is also reported affording gram an hour throughput.
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External DOI: https://doi.org/10.1039/c8cc02169d
This record's URL: https://www.repository.cam.ac.uk/handle/1810/278132
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/
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