Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow.
Authors
Rahman, Husaini BA
Sedelmeier, Joerg
Ley, Steven
Publication Date
2018-05Journal Title
Chemical communications (Cambridge, England)
ISSN
1359-7345
Publisher
Royal Society of Chemistry (RSC)
Volume
54
Issue
44
Pages
5606-5609
Language
eng
Type
Article
This Version
VoR
Physical Medium
Print
Metadata
Show full item recordCitation
Lima, F., Grunenberg, L., Rahman, H. B., Labes, R., Sedelmeier, J., & Ley, S. (2018). Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow.. Chemical communications (Cambridge, England), 54 (44), 5606-5609. https://doi.org/10.1039/c8cc02169d
Abstract
We report an acridium-based organic photocatalyst as an efficient
replacement for iridium-based photocatalysts to single electron
oxidise boronic acid derivatives. Furthermore, we applied the
developed catalytic system to the synthesis of four active
pharmaceutical ingredients (APIs). A straightforward scale up
approach using continuous flow photoreactors is also reported
affording gram an hour throughput.
Sponsorship
EPSRC (EP/K009494/1)
EPSRC (EP/K039520/1)
EPSRC (EP/M004120/1)
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1039/c8cc02169d
This record's URL: https://www.repository.cam.ac.uk/handle/1810/278132
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