The developmental origin of brain tumours: a cellular and molecular framework.
Development (Cambridge, England)
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Azzarelli, R., Simons, B., & Philpott, A. (2018). The developmental origin of brain tumours: a cellular and molecular framework.. Development (Cambridge, England), 145 (10)https://doi.org/10.1242/dev.162693
The development of the nervous system relies on the coordinated regulation of stem cell selfrenewal and differentiation. The discovery that brain tumors contain a subpopulation of cells with stem/progenitor characteristics capable of sustaining tumor growth has emphasized the importance of understanding the cellular dynamics and the molecular pathways that regulate neural stem cell behaviour. By focusing on recent work on glioma and medulloblastoma, we review the developmental origin of brain tumors and how lineage-specific mechanisms that regulate stem cell behaviour may be subverted in cancer to promote proliferation and suppress differentiation.
Brain, Humans, Glioma, Medulloblastoma, Brain Neoplasms, Cell Transformation, Neoplastic, Signal Transduction, Cell Differentiation, Cell Proliferation, Neoplastic Stem Cells, Neural Stem Cells, Cell Self Renewal
This work was funded by MRC Research Grants (MR/K018329/1 (AP/RA), MR/L021129/1 (AP) and Neuroblastoma UK (AP), a Wellcome Trust Senior Investigator Award (098357/Z/12/Z (BDS/RA) and received core support from Wellcome Trust and MRC Cambridge Stem Cell Institute and the Cancer Research UK Cambridge Institute. We are grateful to members of the Philpott and Simons labs for useful discussions.
WELLCOME TRUST (098357/Z/12/Z)
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External DOI: https://doi.org/10.1242/dev.162693
This record's URL: https://www.repository.cam.ac.uk/handle/1810/278152
Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/
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