The developmental origin of brain tumours: a cellular and molecular framework.
Publication Date
2018-05-14Journal Title
Development (Cambridge, England)
ISSN
0950-1991
Volume
145
Issue
10
Language
eng
Type
Article
This Version
VoR
Physical Medium
Electronic
Metadata
Show full item recordCitation
Azzarelli, R., Simons, B., & Philpott, A. (2018). The developmental origin of brain tumours: a cellular and molecular framework.. Development (Cambridge, England), 145 (10)https://doi.org/10.1242/dev.162693
Abstract
The development of the nervous system relies on the coordinated regulation of stem cell selfrenewal
and differentiation. The discovery that brain tumors contain a subpopulation of cells with
stem/progenitor characteristics capable of sustaining tumor growth has emphasized the importance
of understanding the cellular dynamics and the molecular pathways that regulate neural stem cell
behaviour. By focusing on recent work on glioma and medulloblastoma, we review the
developmental origin of brain tumors and how lineage-specific mechanisms that regulate stem cell
behaviour may be subverted in cancer to promote proliferation and suppress differentiation.
Keywords
Brain, Humans, Glioma, Medulloblastoma, Brain Neoplasms, Cell Transformation, Neoplastic, Signal Transduction, Cell Differentiation, Cell Proliferation, Neoplastic Stem Cells, Neural Stem Cells, Cell Self Renewal
Sponsorship
This work was funded by MRC Research Grants (MR/K018329/1 (AP/RA), MR/L021129/1 (AP)
and Neuroblastoma UK (AP), a Wellcome Trust Senior Investigator Award (098357/Z/12/Z
(BDS/RA) and received core support from Wellcome Trust and MRC Cambridge Stem Cell
Institute and the Cancer Research UK Cambridge Institute. We are grateful to members of the
Philpott and Simons labs for useful discussions.
Funder references
WELLCOME TRUST (098357/Z/12/Z)
MRC (MC_PC_12009)
MRC (MR/K018329/1)
MRC (MR/L021129/1)
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1242/dev.162693
This record's URL: https://www.repository.cam.ac.uk/handle/1810/278152
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