Immune Activation in Sepsis.
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Publication Date
2018-01Journal Title
Crit Care Clin
ISSN
0749-0704
Publisher
Elsevier BV
Volume
34
Issue
1
Pages
29-42
Language
eng
Type
Article
This Version
AM
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Conway-Morris, A., Wilson, J., & Shankar-Hari, M. (2018). Immune Activation in Sepsis.. Crit Care Clin, 34 (1), 29-42. https://doi.org/10.1016/j.ccc.2017.08.002
Abstract
Sepsis is caused by a dysregulated host response to infection. Immune responses determine the characteristics of sepsis. The body's protection against infection involves danger signal surveillance and recognition from nonself, effector functions in response to sensing danger signals, homeostatic regulation, and generation of immunologic memory. During sepsis, the immune system is activated by pathogen-associated and host-derived molecular patterns. Detecting these molecular patterns generates multisystem responses. Impaired organ function remote to the site of infection is the unifying feature. The processes by which an appropriate response to a microbial invader change from adaptive to maladaptive and dysregulated remain unclear.
Keywords
Humans, Sepsis, Inflammation, Immunosuppression, Host-Pathogen Interactions, Immunity, Innate
Sponsorship
Wellcome Trust (205214/Z/16/Z)
Identifiers
External DOI: https://doi.org/10.1016/j.ccc.2017.08.002
This record's URL: https://www.repository.cam.ac.uk/handle/1810/278217
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: http://creativecommons.org/licenses/by-nc-nd/4.0/
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