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Reproducibility of cardiac 31P MRS at 7 T

Accepted version
Peer-reviewed

Type

Conference Object

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Authors

Ellis, Jane 
Valkovic, Ladislav 
Purvis, Lucian AB 
Clarke, William T 
Rodgers, CT 

Abstract

Synopsis Cardiac PCr/ATP ratios measured by P MRS change in cardiovascular disease giving them value as a biomarker. We scanned 13 healthy volunteers at 7T, assessing their PCr/ATP with 6 ½ min P CSI scans. These data have better reproducibility than a 30min 3T protocol previously published by our centre. Repeated PCr/ATP measurements from subjects in this study were not significantly (P=0.83) different. Measurements were significantly different (P<0.001) from DCM patient data acquired in a previous 7T study using the same coil and pulse sequence. This data will allow us to plan future 7T P-MRS clinical studies.

Description

Keywords

Journal Title

Proceedings of the International Society for Magnetic Resonance in Medicine

Conference Name

ISMRM 2018

Journal ISSN

Volume Title

Publisher

International Society for Magnetic Resonance in Medicine
Sponsorship
Wellcome Trust (Unknown)
Funded by a Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society (Grant No. 098436/Z/12/Z). JE receives a DPhil (PhD) studentship from the Medical Research Council (UK).