Electrophysiological stimulation of excised rat muscle elicits a measurable change in tissue sodium concentration using 23Na-MRI
Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM)
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Riemer, F., Kaggie, J., O'Neill, C., McLean, M., Grist, J., Hill, M., Guy, J., et al. (2018). Electrophysiological stimulation of excised rat muscle elicits a measurable change in tissue sodium concentration using 23Na-MRI. http://indexsmart.mirasmart.com/ISMRM2018/login.php https://doi.org/10.17863/CAM.25746
Changes in the tissue sodium gradient play an important role in cell signalling such as at the neuromuscular junction and as part of neuronal action potentials. 23Na-MRI has the ability to measure the macroscopic sodium distribution. In this study we investigated the changes in tissue sodium in an electrically stimulated and freshly excised rat leg muscle.
This work was supported by CRUK [C8742/A18097]. This is a contribution from the Cancer Imaging Centre in Cambridge & Manchester, which is funded by the EPSRC and Cancer Research UK. We would like to express our gratitude to the Experimental Cancer Medicine Centres (ECMC) for continued support. JK receives funding support from GlaxoSmithKline.
Cancer Research UK (16465)
This record's DOI: https://doi.org/10.17863/CAM.25746
This record's URL: https://www.repository.cam.ac.uk/handle/1810/278400