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dc.contributor.authorHansen, Maleneen
dc.contributor.authorRubinsztein, Daviden
dc.contributor.authorWalker, David Wen
dc.date.accessioned2018-07-25T13:58:32Z
dc.date.available2018-07-25T13:58:32Z
dc.date.issued2018-09en
dc.identifier.issn1471-0072
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/278442
dc.description.abstractAutophagy is a conserved process that catabolizes intracellular components to maintain energy homeostasis and protect the cell against stressful conditions. Accordingly, it has been shown to play critical roles not only during development and disease, but accumulating evidence over the past decade also supports a direct role for autophagy in the ageing process. In particular, elegant studies using yeast, worms, flies, and mice have demonstrated a broad requirement for autophagy-related genes in the long lifespan observed in a number of conserved longevity paradigms. Moreover, several new and interesting concepts relevant to autophagy and its role in modulating longevity have been highlighted: (i) tissue-specific overexpression of single autophagy genes is sufficient to extend lifespan, (ii) selective types of autophagy may be critical for longevity, and (iii) autophagy can act in cell non-autonomous ways to influence organismal health and ageing. Understanding these mechanisms will be critical for modulating autophagy in approaches aimed at improving human healthspan.
dc.format.mediumPrinten
dc.languageengen
dc.publisherSpringer Nature
dc.titleAutophagy as a promoter of longevity: insights from model organisms.en
dc.typeArticle
prism.endingPage593
prism.issueIdentifier9en
prism.publicationDate2018en
prism.publicationNameNature reviews. Molecular cell biologyen
prism.startingPage579
prism.volume19en
dc.identifier.doi10.17863/CAM.25782
dcterms.dateAccepted2018-04-05en
rioxxterms.versionofrecord10.1038/s41580-018-0033-yen
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-09en
dc.contributor.orcidRubinsztein, David [0000-0001-5002-5263]
dc.identifier.eissn1471-0080
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (095317/Z/11/Z)
pubs.funder-project-idWellcome Trust (100140/Z/12/Z)
rioxxterms.freetoread.startdate2019-01-13


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