Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition.
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Authors
Sen, Abhijit
Papadimitriou, Nikos
Lagiou, Pagona
Travis, Ruth C
Key, Timothy J
Gunter, Marc
Freisling, Heinz
Tzoulaki, Ioanna
Muller, David C
Cross, Amanda J
Lopez, David S
Bergmann, Manuela
Boeing, Heiner
Bamia, Christina
Kotanidou, Anastasia
Karakatsani, Anna
Tjønneland, Anne
Outzen, Malene
Redondo, María-Luisa
Cayssials, Valerie
Chirlaque, Maria-Dolores
Barricarte, Aurelio
Sánchez, Maria-Jose
Larrañaga, Nerea
Tumino, Rosario
Grioni, Sara
Caini, Saverio
Bueno-de-Mesquita, Bas
Nilsson, Lena Maria
Landberg, Rikard
Wallström, Peter
Bech, Bodil Hammer
Overvad, Kim
Aune, Dagfinn
Khaw, Kay-Tee
Riboli, Elio
Trichopoulos, Dimitrios
Trichopoulou, Antonia
Publication Date
2019-01-15Journal Title
Int J Cancer
ISSN
0020-7136
Publisher
Wiley
Volume
144
Issue
2
Pages
240-250
Language
eng
Type
Article
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Sen, A., Papadimitriou, N., Lagiou, P., Perez-Cornago, A., Travis, R. C., Key, T. J., Murphy, N., et al. (2019). Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition.. Int J Cancer, 144 (2), 240-250. https://doi.org/10.1002/ijc.31634
Abstract
The epidemiological evidence regarding the association of coffee and tea consumption with prostate cancer risk is inconclusive, and few cohort studies have assessed these associations by disease stage and grade. We examined the associations of coffee (total, caffeinated and decaffeinated) and tea intake with prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition. Among 142,196 men, 7,036 incident prostate cancer cases were diagnosed over 14 years of follow-up. Data on coffee and tea consumption were collected through validated country-specific food questionnaires at baseline. We used Cox proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (CI). Models were stratified by center and age, and adjusted for anthropometric, lifestyle and dietary factors. Median coffee and tea intake were 375 and 106 mL/day, respectively, but large variations existed by country. Comparing the highest (median of 855 mL/day) versus lowest (median of 103 mL/day) consumers of coffee and tea (450 vs. 12 mL/day) the HRs were 1.02 (95% CI, 0.94-1.09) and 0.98 (95% CI, 0.90-1.07) for risk of total prostate cancer and 0.97 (95% CI, 0.79-1.21) and 0.89 (95% CI, 0.70-1.13) for risk of fatal disease, respectively. No evidence of association was seen for consumption of total, caffeinated or decaffeinated coffee or tea and risk of total prostate cancer or cancer by stage, grade or fatality in this large cohort. Further investigations are needed to clarify whether an association exists by different preparations or by concentrations and constituents of these beverages.
Keywords
Humans, Prostatic Neoplasms, Diet Surveys, Incidence, Proportional Hazards Models, Risk Factors, Cohort Studies, Coffee, Tea, Adult, Aged, Middle Aged, Europe, Male
Sponsorship
Medical Research Council (G1000143)
Identifiers
External DOI: https://doi.org/10.1002/ijc.31634
This record's URL: https://www.repository.cam.ac.uk/handle/1810/279657
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