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dc.contributor.authorLi, Jingmei
dc.contributor.authorLindström, Linda S
dc.contributor.authorFoo, Jia N
dc.contributor.authorRafiq, Sajjad
dc.contributor.authorSchmidt, Marjanka K
dc.contributor.authorPharoah, Paul
dc.contributor.authorMichailidou, Kyriaki
dc.contributor.authorDennis, Joe
dc.contributor.authorBolla, Manjeet K
dc.contributor.authorWang, Jean
dc.contributor.authorVan 't Veer, Laura J
dc.contributor.authorCornelissen, Sten
dc.contributor.authorRutgers, Emiel
dc.contributor.authorSouthey, Melissa C
dc.contributor.authorApicella, Carmel
dc.contributor.authorDite, Gillian S
dc.contributor.authorHopper, John L
dc.contributor.authorFasching, Peter A
dc.contributor.authorHaeberle, Lothar
dc.contributor.authorEkici, Arif B
dc.contributor.authorBeckmann, Matthias W
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorMuranen, Taru A
dc.contributor.authorAittomäki, Kristiina
dc.contributor.authorLindblom, Annika
dc.contributor.authorMargolin, Sara
dc.contributor.authorMannermaa, Arto
dc.contributor.authorKosma, Veli-Matti
dc.contributor.authorHartikainen, Jaana M
dc.contributor.authorKataja, Vesa
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorkConFab Investigators
dc.contributor.authorPhillips, Kelly-Anne
dc.contributor.authorMcLachlan, Sue-Anne
dc.contributor.authorLambrechts, Diether
dc.contributor.authorThienpont, Bernard
dc.contributor.authorSmeets, Ann
dc.contributor.authorWildiers, Hans
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorFlesch-Janys, Dieter
dc.contributor.authorSeibold, Petra
dc.contributor.authorRudolph, Anja
dc.contributor.authorGiles, Graham G
dc.contributor.authorBaglietto, Laura
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorHaiman, Christopher A
dc.contributor.authorHenderson, Brian E
dc.contributor.authorSchumacher, Fredrick
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorKristensen, Vessela
dc.contributor.authorAlnæs, Grethe I Grenaker
dc.contributor.authorBorresen-Dale, Anne-Lise
dc.contributor.authorNord, Silje
dc.contributor.authorWinqvist, Robert
dc.contributor.authorPylkäs, Katri
dc.contributor.authorJukkola-Vuorinen, Arja
dc.contributor.authorGrip, Mervi
dc.contributor.authorAndrulis, Irene L
dc.contributor.authorKnight, Julia A
dc.contributor.authorGlendon, Gord
dc.contributor.authorTchatchou, Sandrine
dc.contributor.authorDevilee, Peter
dc.contributor.authorTollenaar, Robert
dc.contributor.authorSeynaeve, Caroline
dc.contributor.authorHooning, Maartje
dc.contributor.authorKriege, Mieke
dc.contributor.authorHollestelle, Antoinette
dc.contributor.authorvan den Ouweland, Ans
dc.contributor.authorLi, Yi
dc.contributor.authorHamann, Ute
dc.contributor.authorTorres, Diana
dc.contributor.authorUlmer, Hans U
dc.contributor.authorRüdiger, Thomas
dc.contributor.authorShen, Chen-Yang
dc.contributor.authorHsiung, Chia-Ni
dc.contributor.authorWu, Pei-Ei
dc.contributor.authorChen, Shou-Tung
dc.contributor.authorTeo, Soo Hwang
dc.contributor.authorTaib, Nur Aishah Mohd
dc.contributor.authorHar Yip, Cheng
dc.contributor.authorFuang Ho, Gwo
dc.contributor.authorMatsuo, Keitaro
dc.contributor.authorIto, Hidemi
dc.contributor.authorIwata, Hiroji
dc.contributor.authorTajima, Kazuo
dc.contributor.authorKang, Daehee
dc.contributor.authorChoi, Ji-Yeob
dc.contributor.authorPark, Sue K
dc.contributor.authorYoo, Keun-Young
dc.contributor.authorMaishman, Tom
dc.contributor.authorTapper, William J
dc.contributor.authorDunning, Alison
dc.contributor.authorShah, Mitul
dc.contributor.authorLuben, Robert
dc.contributor.authorBrown, Judith
dc.contributor.authorKhor, Chiea Chuen
dc.contributor.authorEccles, Diana M
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorEaston, Douglas
dc.contributor.authorHumphreys, Keith
dc.contributor.authorLiu, Jianjun
dc.contributor.authorHall, Per
dc.contributor.authorCzene, Kamila
dc.date.accessioned2018-09-10T22:18:05Z
dc.date.available2018-09-10T22:18:05Z
dc.date.issued2014-06-17
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280096
dc.description.abstractLarge population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectkConFab Investigators
dc.subjectChromosomes, Human, Pair 2
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectGenetic Markers
dc.subjectPrognosis
dc.subjectDrug Therapy
dc.subjectProportional Hazards Models
dc.subjectLinkage Disequilibrium
dc.subjectPolymorphism, Single Nucleotide
dc.subjectEuropean Continental Ancestry Group
dc.subjectFemale
dc.subjectKaplan-Meier Estimate
dc.title2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy.
dc.typeArticle
prism.publicationDate2014
prism.publicationNameNat Commun
prism.startingPage4051
prism.volume5
dc.identifier.doi10.17863/CAM.27460
dcterms.dateAccepted2014-05-06
rioxxterms.versionofrecord10.1038/ncomms5051
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2014-06-17
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.contributor.orcidDennis, Joe [0000-0003-4591-1214]
dc.contributor.orcidWang, Jean [0000-0002-9139-0627]
dc.contributor.orcidDunning, Alison [0000-0001-6651-7166]
dc.contributor.orcidLuben, Robert [0000-0002-5088-6343]
dc.contributor.orcidEaston, Douglas [0000-0003-2444-3247]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Review
pubs.funder-project-idNational Cancer Institute (U19CA148537)
pubs.funder-project-idNational Cancer Institute (R01CA128978)
pubs.funder-project-idNational Cancer Institute (U19CA148065)
pubs.funder-project-idEuropean Commission (223175)
pubs.funder-project-idCancer Research UK (CRUK-A10710)
pubs.funder-project-idCancer Research UK (CRUK-A12014)
pubs.funder-project-idCancer Research UK (CRUK-A10118)
pubs.funder-project-idBreast Cancer Now (2010NovPR62)
cam.issuedOnline2014-06-17


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Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)