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dc.contributor.authorBailey, Peteren
dc.contributor.authorNathan, Jamesen
dc.date.accessioned2018-09-20T12:01:17Z
dc.date.available2018-09-20T12:01:17Z
dc.date.issued2018-05-17en
dc.identifier.issn2227-9059
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280381
dc.description.abstractHypoxia-inducible transcription factors (HIFs) facilitate cellular adaptations to low-oxygen environments. However, it is increasingly recognised that HIFs may be activated in response to metabolic stimuli, even when oxygen is present. Understanding the mechanisms for the crosstalk that exists between HIF signalling and metabolic pathways is therefore important. This review focuses on this metabolic regulation of HIFs by small molecule metabolites and iron, highlighting the latest studies that explore how Tricarboxylic Acid (TCA) cycle intermediates, 2-hydroxyglutarate (2-HG) or intracellular iron levels influence the HIF response through modulating the activity of prolyl hydroxylases (PHDs). We also discuss the relevance of these metabolic pathways in physiological and disease contexts. Lastly, as PHDs are members of a large family of 2-oxoglutarate (2-OG) dependent dioxygenases that can all respond to metabolic stimuli, we explore the broader role of TCA cycle metabolites and 2-HG in the regulation of 2-OG dependent dioxygenases, focusing on those enzymes involved in chromatin remodelling.
dc.format.mediumElectronicen
dc.languageengen
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleMetabolic Regulation of Hypoxia-Inducible Transcription Factors: The Role of Small Molecule Metabolites and Iron.en
dc.typeArticle
prism.issueIdentifier2en
prism.publicationDate2018en
prism.publicationNameBiomedicinesen
prism.volume6en
dc.identifier.doi10.17863/CAM.27752
dcterms.dateAccepted2018-05-15en
rioxxterms.versionofrecord10.3390/biomedicines6020060en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-05-17en
dc.contributor.orcidBailey, Peter [0000-0001-7707-3521]
dc.contributor.orcidNathan, James Alexander [0000-0002-0248-1632]
dc.identifier.eissn2227-9059
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (102770/Z/13/Z)
pubs.funder-project-idLister Institute of Preventive Medicine (unknown)
pubs.funder-project-idWellcome Trust (100140/Z/12/Z)
pubs.funder-project-idWellcome Trust (205252/Z/16/Z)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International