Show simple item record

dc.contributor.authorBlanchard, Guy
dc.contributor.authorFletcher, Alexander G
dc.contributor.authorSchumacher, Linus J
dc.date.accessioned2018-09-20T12:05:39Z
dc.date.available2018-09-20T12:05:39Z
dc.date.issued2019-09
dc.identifier.issn1084-9521
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280507
dc.description.abstractHeterogeneity within cell populations can be an important aspect affecting their collective movement and tissue-mechanical properties, determining for example their effective viscoelasticity. Differences in cell-level properties and behaviour within a group of moving cells can give rise to unexpected and non-intuitive behaviours at the tissue level. Such emergent phenomena often manifest themselves through spatiotemporal patterns at an intermediate 'mesoscale' between cell and tissue scales, typically involving tens of cells. Focussing on the development of embryonic animal tissues, we review recent evidence for the importance of heterogeneity at the mesoscale for collective cell migration and convergence and extension movements. We further discuss approaches to incorporate heterogeneity into computational models to complement experimental investigations.
dc.description.sponsorshipGBB acknowledges the Wellcome Trust Investigator Award 099234/Z/12/Z to Bénédicte Sanson. AGF is supported by a Vice-Chancellor’s Fellowship from the University of Sheffield. LJS is supported by a Chancellor’s Fellowship from the University of Edinburgh.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier BV
dc.subjectHumans
dc.subjectCell Movement
dc.titleThe devil is in the mesoscale: Mechanical and behavioural heterogeneity in collective cell movement.
dc.typeArticle
prism.endingPage54
prism.publicationDate2019
prism.publicationNameSemin Cell Dev Biol
prism.startingPage46
prism.volume93
dc.identifier.doi10.17863/CAM.27877
dcterms.dateAccepted2018-06-18
rioxxterms.versionofrecord10.1016/j.semcdb.2018.06.003
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-09
dc.contributor.orcidBlanchard, Guy [0000-0002-3689-0522]
dc.identifier.eissn1096-3634
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (099234/Z/12/Z)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/J010278/1)
rioxxterms.freetoread.startdate2019-06-27


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record