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dc.contributor.authorRojas, Lyda Z
dc.contributor.authorGlisic, Marija
dc.contributor.authorPletsch-Borba, Laura
dc.contributor.authorEcheverría, Luis E
dc.contributor.authorBramer, Wichor M
dc.contributor.authorBano, Arjola
dc.contributor.authorStringa, Najada
dc.contributor.authorZaciragic, Asija
dc.contributor.authorKraja, Bledar
dc.contributor.authorAsllanaj, Eralda
dc.contributor.authorChowdhury, Rajiv
dc.contributor.authorMorillo, Carlos A
dc.contributor.authorRueda-Ochoa, Oscar L
dc.contributor.authorFranco, Oscar H
dc.contributor.authorMuka, Taulant
dc.date.accessioned2018-09-20T12:06:40Z
dc.date.available2018-09-20T12:06:40Z
dc.date.issued2018-06
dc.identifier.issn1935-2727
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280535
dc.description.abstractBACKGROUND: Chagas disease (CD) is a major public health concern in Latin America and a potentially serious emerging threat in non-endemic countries. Although the association between CD and cardiac abnormalities is widely reported, study design diversity, sample size and quality challenge the information, calling for its update and synthesis, which would be very useful and relevant for physicians in non-endemic countries where health care implications of CD are real and neglected. We performed to systematically review and meta-analyze population-based studies that compared prevalence of overall and specific ECG abnormalities between CD and non-CD participants in the general population. METHODS: Six databases (EMBASE, Ovid Medline, Web of Science, Cochrane Central, Google Scholar and Lilacs) were searched systematically. Observational studies were included. Odds ratios (OR) were computed using random-effects model. RESULTS: Forty-nine studies were selected, including 34,023(12,276 CD and 21,747 non-CD). Prevalence of overall ECG abnormalities was higher in participants with CD (40.1%; 95%CIs=39.2-41.0) compared to non-CD (24.1%; 95%CIs=23.5-24.7) (OR=2.78; 95%CIs=2.37-3.26). Among specific ECG abnormalities, prevalence of complete right bundle branch block (RBBB) (OR=4.60; 95%CIs=2.97-7.11), left anterior fascicular block (LAFB) (OR=1.60; 95%CIs=1.21-2.13), combination of complete RBBB/LAFB (OR=3.34; 95%CIs=1.76-6.35), first-degree atrioventricular block (A-V B) (OR=1.71; 95%CIs=1.25-2.33), atrial fibrillation (AF) or flutter (OR=2.11; 95%CIs=1.40-3.19) and ventricular extrasystoles (VE) (OR=1.62; 95%CIs=1.14-2.30) was higher in CD compared to non-CD participants. CONCLUSIONS: This systematic review and meta-analysis provides an update and synthesis in this field. This research of observational studies indicates a significant excess in prevalence of ECG abnormalities (40.1%) related to T. cruzi infection in the general population from Chagas endemic regions, being the most common ventricular (RBBB and LAFB), and A-V B (first-degree) node conduction abnormalities as well as arrhythmias (AF or flutter and VE). Also, prevalence of ECG alterations in children was similar to that in adults and suggests earlier onset of cardiac disease.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHeart Conduction System
dc.subjectHumans
dc.subjectChagas Disease
dc.subjectChagas Cardiomyopathy
dc.subjectElectrocardiography
dc.subjectPrevalence
dc.subjectOdds Ratio
dc.subjectAdult
dc.subjectChild
dc.subjectFemale
dc.subjectMale
dc.subjectArrhythmias, Cardiac
dc.subjectObservational Studies as Topic
dc.titleElectrocardiographic abnormalities in Chagas disease in the general population: A systematic review and meta-analysis.
dc.typeArticle
prism.issueIdentifier6
prism.publicationDate2018
prism.publicationNamePLoS Negl Trop Dis
prism.startingPagee0006567
prism.volume12
dc.identifier.doi10.17863/CAM.27904
dcterms.dateAccepted2018-05-29
rioxxterms.versionofrecord10.1371/journal.pntd.0006567
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-06-13
dc.contributor.orcidRojas, Lyda Z [0000-0002-4252-7105]
dc.contributor.orcidPletsch-Borba, Laura [0000-0003-4872-6452]
dc.identifier.eissn1935-2735
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/L003120/1)
pubs.funder-project-idBritish Heart Foundation (None)
cam.issuedOnline2018-06-13


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Except where otherwise noted, this item's licence is described as Attribution 4.0 International