Physical activity intensity, bout-duration, and cardiometabolic risk markers in children and adolescents.
Authors
Child, Abbey
Bugge, Anna
Grøntved, Anders
Wedderkopp, Niels
Andersen, Lars B
Cardon, Greet
Davey, Rachel
Janz, Kathleen F
Kriemler, Susi
Northstone, Kate
Page, Angie S
Puder, Jardena J
Reilly, John J
Sardinha, Luis B
International Children’s Accelerometry Database (ICAD) Collaborators
Publication Date
2018-09Journal Title
Int J Obes (Lond)
ISSN
0307-0565
Publisher
Springer Science and Business Media LLC
Volume
42
Issue
9
Pages
1639-1650
Language
eng
Type
Article
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Tarp, J., Child, A., White, T., Westgate, K., Bugge, A., Grøntved, A., Wedderkopp, N., et al. (2018). Physical activity intensity, bout-duration, and cardiometabolic risk markers in children and adolescents.. Int J Obes (Lond), 42 (9), 1639-1650. https://doi.org/10.1038/s41366-018-0152-8
Abstract
OBJECTIVES: To determine the role of physical activity intensity and bout-duration in modulating associations between physical activity and cardiometabolic risk markers. METHODS: A cross-sectional study using the International Children's Accelerometry Database (ICAD) including 38,306 observations (in 29,734 individuals aged 4-18 years). Accelerometry data was summarized as time accumulated in 16 combinations of intensity thresholds (≥500 to ≥3000 counts/min) and bout-durations (≥1 to ≥10 min). Outcomes were body mass index (BMI, kg/m2), waist circumference, biochemical markers, blood pressure, and a composite score of these metabolic markers. A second composite score excluded the adiposity component. Linear mixed models were applied to elucidate the associations and expressed per 10 min difference in daily activity above the intensity/bout-duration combination. Estimates (and variance) from each of the 16 combinations of intensity and bout-duration examined in the linear mixed models were analyzed in meta-regression to investigate trends in the association. RESULTS: Each 10 min positive difference in physical activity was significantly and inversely associated with the risk factors irrespective of the combination of intensity and bout-duration. In meta-regression, each 1000 counts/min increase in intensity threshold was associated with a -0.027 (95% CI: -0.039 to -0.014) standard deviations lower composite risk score, and a -0.064 (95% CI: -0.09 to -0.038) kg/m2 lower BMI. Conversely, meta-regression suggested bout-duration was not significantly associated with effect-sizes (per 1 min increase in bout-duration: -0.002 (95% CI: -0.005 to 0.0005) standard deviations for the composite risk score, and -0.005 (95% CI: -0.012 to 0.002) kg/m2 for BMI). CONCLUSIONS: Time spent at higher intensity physical activity was the main determinant of variation in cardiometabolic risk factors, not bout-duration. Greater magnitude of associations was consistently observed with higher intensities. These results suggest that, in children and adolescents, physical activity, preferably at higher intensities, of any bout-duration should be promoted.
Keywords
International Children’s Accelerometry Database (ICAD) Collaborators, Humans, Cardiovascular Diseases, Obesity, Insulin, Blood Glucose, Body Mass Index, Exercise, Risk Factors, Cross-Sectional Studies, Blood Pressure, Adolescent, Child, Child, Preschool, Waist Circumference, Physical Conditioning, Human, Biomarkers
Sponsorship
Medical Research Council (MC_UU_12015/3)
Medical Research Council (MC_UU_12015/7)
Wellcome Trust (087636/Z/08/Z)
Economic and Social Research Council (ES/G007462/1)
Medical Research Council (MR/K023187/1)
British Heart Foundation (None)
Medical Research Council (G0701877)
Identifiers
External DOI: https://doi.org/10.1038/s41366-018-0152-8
This record's URL: https://www.repository.cam.ac.uk/handle/1810/282795
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