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dc.contributor.authorFehlings, Michael G
dc.contributor.authorTetreault, Lindsay A
dc.contributor.authorAarabi, Bizhan
dc.contributor.authorAnderson, Paul
dc.contributor.authorArnold, Paul M
dc.contributor.authorBrodke, Darrel S
dc.contributor.authorBurns, Anthony S
dc.contributor.authorChiba, Kazuhiro
dc.contributor.authorDettori, Joseph R
dc.contributor.authorFurlan, Julio C
dc.contributor.authorHawryluk, Gregory
dc.contributor.authorHolly, Langston T
dc.contributor.authorHowley, Susan
dc.contributor.authorJeji, Tara
dc.contributor.authorKalsi-Ryan, Sukhvinder
dc.contributor.authorKotter, Mark
dc.contributor.authorKurpad, Shekar
dc.contributor.authorKwon, Brian K
dc.contributor.authorMarino, Ralph J
dc.contributor.authorMartin, Allan R
dc.contributor.authorMassicotte, Eric
dc.contributor.authorMerli, Geno
dc.contributor.authorMiddleton, James W
dc.contributor.authorNakashima, Hiroaki
dc.contributor.authorNagoshi, Narihito
dc.contributor.authorPalmieri, Katherine
dc.contributor.authorSingh, Anoushka
dc.contributor.authorSkelly, Andrea C
dc.contributor.authorTsai, Eve C
dc.contributor.authorVaccaro, Alexander
dc.contributor.authorWilson, Jefferson R
dc.contributor.authorYee, Albert
dc.contributor.authorHarrop, James S
dc.date.accessioned2018-09-29T06:07:36Z
dc.date.available2018-09-29T06:07:36Z
dc.date.issued2017-09-01
dc.identifier.issn2192-5682
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/282887
dc.description.abstractIntroduction: The objective of this study is to develop evidence-based guidelines that recommend effective, safe and cost-effective thromboprophylaxis strategies in patients with spinal cord injury (SCI). Methods: A systematic review of the literature was conducted to address key questions relating to thromboprophylaxis in SCI. Based on GRADE (Grading of Recommendation, Assessment, Development and Evaluation), a strong recommendation is worded as "we recommend," whereas a weaker recommendation is indicated by "we suggest." Results: Based on conclusions from the systematic review and expert panel opinion, the following recommendations were developed: (1) "We suggest that anticoagulant thromboprophylaxis be offered routinely to reduce the risk of thromboembolic events in the acute period after SCI;" (2) "We suggest that anticoagulant thromboprophylaxis, consisting of either subcutaneous low-molecular-weight heparin or fixed, low-dose unfractionated heparin (UFH) be offered to reduce the risk of thromboembolic events in the acute period after SCI. Given the potential for increased bleeding events with the use of adjusted-dose UFH, we suggest against this option;" (3) "We suggest commencing anticoagulant thromboprophylaxis within the first 72 hours after injury, if possible, in order to minimize the risk of venous thromboembolic complications during the period of acute hospitalization." Conclusions: These guidelines should be implemented into clinical practice in patients with SCI to promote standardization of care, decrease heterogeneity of management strategies and encourage clinicians to make evidence-informed decisions.
dc.languageeng
dc.publisherSAGE
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleA Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Type and Timing of Anticoagulant Thromboprophylaxis.
dc.typeArticle
prism.endingPage220S
prism.issueIdentifier3 Suppl
prism.publicationDate2017
prism.publicationNameGlobal Spine Journal
prism.startingPage212S
prism.volume7
dc.identifier.doi10.17863/CAM.30250
rioxxterms.versionofrecord10.1177/2192568217702107
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-09-01
dc.contributor.orcidKotter, Mark [0000-0001-5145-7199]
dc.identifier.eissn2192-5690
rioxxterms.typeJournal Article/Review
cam.issuedOnline2017-09-05


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International