BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-κB and Activating PKA/CREB.
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Authors
Li, Chuwen
Chen, Tongkai
Zhou, Hefeng
Feng, Yu
Hoi, Maggie PM
Ma, Dan
Zheng, Ying
Lee, Simon MY
Publication Date
2018Journal Title
Front Pharmacol
ISSN
1663-9812
Publisher
Frontiers Media SA
Volume
9
Pages
614
Language
eng
Type
Article
Physical Medium
Electronic-eCollection
Metadata
Show full item recordCitation
Li, C., Chen, T., Zhou, H., Feng, Y., Hoi, M. P., Ma, D., Zhao, C., et al. (2018). BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-κB and Activating PKA/CREB.. Front Pharmacol, 9 614. https://doi.org/10.3389/fphar.2018.00614
Abstract
Microglia-mediated neuroinflammatory responses are inevitable and important pathological processes in several kinds of disorder of the central nervous system (CNS). Therefore, alleviating activated microglia-induced inflammatory process might be a valuable therapeutic approach to neuroinflammation-related diseases. In the present study, we investigated BHDPC, a novel neuroprotectant discovered in our previous study that had anti-inflammatory effects under neuroinflammatory conditions. First, we found that BHDPC could inhibit neuroinflammatory responses and promote microglial M2 phenotype polarization in both lipopolysaccharide (LPS)-activated BV-2 microglia l cells. Furthermore, BHDPC provided protective actions against neuroinflammation-induced neurotoxicity in HT22 mouse hippocampal cells co-cultured with activated BV-2 microglia. Further experiments demonstrated that BHDPC could suppress LPS-induced activation of transcription factor nuclear factor kappa B (NF-κB) via interfering with the degradation of the inhibitor of kappa B (IκB) and phosphorylation of IκB, the IκB kinase (IKK). Moreover, we also found that BHDPC could induce phosphorylation of cAMP-dependent protein kinase A (PKA) and cAMP-response element-binding protein (CREB) in BV-2 microglial cells. Also, using the PKA-specific inhibitor, we found that BHDPC-induced CREB phosphorylation was dependent on PKA, which also contributed to BHDPC-mediated anti-inflammation and neuroprotection.
Keywords
BHDPC, CREB, NF-κB, PKA, microglia, neuroinflammation
Identifiers
External DOI: https://doi.org/10.3389/fphar.2018.00614
This record's URL: https://www.repository.cam.ac.uk/handle/1810/283050
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