Cell cycle-dependent phosphorylation and regulation of cellular differentiation.
Hardwick, Laura JA
Biochem Soc Trans
Portland Press Ltd.
MetadataShow full item record
Hardwick, L. J., Azzarelli, R., & Philpott, A. (2018). Cell cycle-dependent phosphorylation and regulation of cellular differentiation.. Biochem Soc Trans, 46 (5), 1083-1091. https://doi.org/10.1042/BST20180276
Embryogenesis requires an exquisite regulation of cell proliferation, cell cycle withdrawal and differentiation into a massively diverse range of cells at the correct time and place. Stem cells also remain to varying extents in different adult tissues, acting in tissue homeostasis and repair. Therefore, regulated proliferation and subsequent differentiation of stem and progenitor cells remains pivotal throughout life. Recent advances have characterised the cell cycle dynamics, epigenetics, transcriptome and proteome accompanying the transition from proliferation to differentiation, revealing multiple bidirectional interactions between the cell cycle machinery and factors driving differentiation. Here, we focus on a direct mechanistic link involving phosphorylation of differentiation-associated transcription factors by cell cycle-associated Cyclin-dependent kinases. We discuss examples from the three embryonic germ layers to illustrate this regulatory mechanism that co-ordinates the balance between cell proliferation and differentiation.
cell cycle, cell differentiation, phosphorylation/dephosphorylation, transcription factors, Animals, Cell Cycle, Cell Differentiation, Cell Lineage, Cell Proliferation, Chromatin, Cyclin-Dependent Kinases, Ectoderm, Embryonic Development, Epigenesis, Genetic, Homeostasis, Humans, Mesoderm, Phosphorylation, Proteome, Stem Cells, Transcription Factors, Transcriptome
This work was funded by MRC Research Grants (MR/K018329/1 (AP/RA), MR/L021129/1 (AP)Neuroblastoma UK (AP) and the Rosetrees and Stoneygate Trusts (AP/RA). LH is supported by a Peterhouse Research Fellowship
Medical Research Council (MC_PC_12009)
Medical Research Council (MR/K018329/1)
Medical Research Council (MR/L021129/1)
External DOI: https://doi.org/10.1042/BST20180276
This record's URL: https://www.repository.cam.ac.uk/handle/1810/283056
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: firstname.lastname@example.org