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dc.contributor.authorPaese, Christian Louis Bonatto
dc.contributor.authorSchoenauer, Anna
dc.contributor.authorLeite, Daniel J
dc.contributor.authorRussell, Steve
dc.contributor.authorMcGregor, Alistair P
dc.date.accessioned2018-10-03T04:45:30Z
dc.date.available2018-10-03T04:45:30Z
dc.date.issued2018-08-21
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283095
dc.description.abstractSox genes encode a set of highly conserved transcription factors that regulate many developmental processes. In insects, the SoxB gene Dichaete is the only Sox gene known to be involved in segmentation. To determine if similar mechanisms are used in other arthropods, we investigated the role of Sox genes during segmentation in the spider Parasteatoda tepidariorum. While Dichaete does not appear to be involved in spider segmentation, we found that the closely related Sox21b-1 gene acts as a gap gene during formation of anterior segments and is also part of the segmentation clock for development of the segment addition zone and sequential addition of opisthosomal segments. Thus, we have found that two different mechanisms of segmentation in a non-mandibulate arthropod are regulated by a SoxB gene. Our work provides new insights into the function of an important and conserved gene family, and the evolution of the regulation of segmentation in arthropods.
dc.format.mediumElectronic
dc.languageeng
dc.publishereLife Sciences Publications, Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnimals
dc.subjectSpiders
dc.subjectGene Expression Regulation, Developmental
dc.subjectBody Patterning
dc.subjectSOXB2 Transcription Factors
dc.subjectBiological Evolution
dc.titleA SoxB gene acts as an anterior gap gene and regulates posterior segment addition in a spider.
dc.typeArticle
prism.publicationDate2018
prism.publicationNameElife
prism.volume7
dc.identifier.doi10.17863/CAM.30457
dcterms.dateAccepted2018-08-10
rioxxterms.versionofrecord10.7554/eLife.37567
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-08-21
dc.contributor.orcidPaese, Christian Louis Bonatto [0000-0001-5992-5209]
dc.contributor.orcidRussell, Steve [0000-0003-0546-3031]
dc.contributor.orcidMcGregor, Alistair P [0000-0002-2908-2420]
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/N007069/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/L002817/1)
cam.issuedOnline2018-08-21


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International