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dc.contributor.authorRowland, Matthew J
dc.contributor.authorParkins, Christopher C
dc.contributor.authorMcAbee, Joseph H
dc.contributor.authorKolb, Anna K
dc.contributor.authorHein, Robert
dc.contributor.authorLoh, Xian Jun
dc.contributor.authorWatts, Colin
dc.contributor.authorScherman, Oren A
dc.date.accessioned2018-10-10T05:16:27Z
dc.date.available2018-10-10T05:16:27Z
dc.date.issued2018-10
dc.identifier.issn0142-9612
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/283340
dc.description.abstractA physical hydrogel cross-linked via the host-guest interactions of cucurbit[8]uril and utilised as an implantable drug-delivery vehicle for the brain is described herein. Constructed from hyaluronic acid, this hydrogel is biocompatible and has a high water content of 98%. The mechanical properties have been characterised by rheology and compared with the modulus of human brain tissue demonstrating the production of a soft material that can be moulded into the cavity it is implanted into following surgical resection. Furthermore, effective delivery of therapeutic compounds and antibodies to primary human glioblastoma cell lines is showcased by a variety of in vitro and ex vivo viability and immunocytochemistry based assays.
dc.description.sponsorshipThis work was supported by The Brain Tumour Charity (RG89672), the National Institute for Health Research Cambridge Biomedical Research Centre; the Higher Education Funding Council for England. We acknowledge the Human Research Tissue Bank and Biomedical Research Centre for the tissue being accessed through the Human Research Tissue Bank. The Human Research Tissue Bank is supported by the NIHR Cambridge Biomedical Research Centre. MJR thanks the University of Cambridge Chemical Biology and Molecular Medicine PhD Training Programme for funding. CCP is thankful for the support of the EPSRC and the Brain Tumour Charity for funding. JHM acknowledges the support of the Gates Cambridge Scholarship programme. AKK was supported by a studentship from the John and Lucille van Geest Foundation.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier BV
dc.subjectBlood-Brain Barrier
dc.subjectBrain
dc.subjectCell Line, Tumor
dc.subjectHumans
dc.subjectGlioma
dc.subjectHyaluronic Acid
dc.subjectHydrogels
dc.subjectDrug Delivery Systems
dc.subjectImmunohistochemistry
dc.subjectCell Survival
dc.titleAn adherent tissue-inspired hydrogel delivery vehicle utilised in primary human glioma models.
dc.typeArticle
prism.endingPage208
prism.publicationDate2018
prism.publicationNameBiomaterials
prism.startingPage199
prism.volume179
dc.identifier.doi10.17863/CAM.30708
dcterms.dateAccepted2018-05-29
rioxxterms.versionofrecord10.1016/j.biomaterials.2018.05.054
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-10
dc.contributor.orcidScherman, Oren [0000-0001-8032-7166]
dc.identifier.eissn1878-5905
rioxxterms.typeJournal Article/Review
pubs.funder-project-idBrain Tumour Charity (495097)
pubs.funder-project-idEPSRC (1652502)
cam.issuedOnline2018-06-04
rioxxterms.freetoread.startdate2019-06-04


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