Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry.
Springer Science and Business Media LLC
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Ritson, D. J., Battilocchio, C., Ley, S., & Sutherland, J. D. (2018). Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry.. Nat Commun, 9 (1), 1821. https://doi.org/10.1038/s41467-018-04147-2
When considering life's aetiology, the first questions that must be addressed are "how?" and "where?" were ostensibly complex molecules, considered necessary for life's beginning, constructed from simpler, more abundant feedstock molecules on primitive Earth. Previously, we have used multiple clues from the prebiotic synthetic requirements of (proto)biomolecules to pinpoint a set of closely related geochemical scenarios that are suggestive of flow and semi-batch chemistries. We now wish to report a multistep, uninterrupted synthesis of a key heterocycle (2-aminooxazole) en route to activated nucleotides starting from highly plausible, prebiotic feedstock molecules under conditions which mimic this scenario. Further consideration of the scenario has uncovered additional pertinent and novel aspects of prebiotic chemistry, which greatly enhance the efficiency and plausibility of the synthesis.
Aldehydes, Oxazoles, Molecular Mimicry, Surface Properties, Physical Phenomena, Photochemical Processes, Origin of Life, Earth, Planet
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (737266)
Engineering and Physical Sciences Research Council (EP/K039520/1)
External DOI: https://doi.org/10.1038/s41467-018-04147-2
This record's URL: https://www.repository.cam.ac.uk/handle/1810/283434
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/