The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders.
Kreutz, Michael R
Front Mol Neurosci
Frontiers Media SA
MetadataShow full item record
Bayraktar, G., & Kreutz, M. R. (2018). The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders.. Front Mol Neurosci, 11 169. https://doi.org/10.3389/fnmol.2018.00169
Over the last decade, an increasing number of reports underscored the importance of epigenetic regulations in brain plasticity. Epigenetic elements such as readers, writers and erasers recognize, establish, and remove the epigenetic tags in nucleosomes, respectively. One such regulation concerns DNA-methylation and demethylation, which are highly dynamic and activity-dependent processes even in the adult neurons. It is nowadays widely believed that external stimuli control the methylation marks on the DNA and that such processes serve transcriptional regulation in neurons. In this mini-review, we cover the current knowledge on the regulatory mechanisms controlling in particular DNA demethylation as well as the possible functional consequences in health and disease.
DNA Methylation, GADD45B, TET enzymes, base excision repair (BER), gene expression, neural disorders, neurons, synaptic plasticity
External DOI: https://doi.org/10.3389/fnmol.2018.00169
This record's URL: https://www.repository.cam.ac.uk/handle/1810/284685
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/
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