The interaction of transcription factors controls the spatial layout of plant aerial stem cell niches.
NPJ Syst Biol Appl
Springer Science and Business Media LLC
MetadataShow full item record
Gruel, J., Deichmann, J., Landrein, B., Hitchcock, T., & Jönsson, H. (2018). The interaction of transcription factors controls the spatial layout of plant aerial stem cell niches.. NPJ Syst Biol Appl, 4 36. https://doi.org/10.1038/s41540-018-0072-1
The plant shoot apical meristem holds a stem cell niche from which all aerial organs originate. Using a computational approach we show that a mixture of monomers and heterodimers of the transcription factors WUSCHEL and HAIRY MERISTEM is sufficient to pattern the stem cell niche, and predict that immobile heterodimers form a regulatory "pocket" surrounding the stem cells. The model achieves to reproduce an array of perturbations, including mutants and tissue size modifications. We also show its ability to reproduce the recently observed dynamical shift of the stem cell niche during the development of an axillary meristem. The work integrates recent experimental results to answer the longstanding question of how the asymmetry of expression between the stem cell marker CLAVATA3 and its activator WUSCHEL is achieved, and recent findings of plasticity in the system.
0601 Biochemistry and Cell Biology, 0604 Genetics, Basic Science, Stem Cell Research - Nonembryonic - Non-Human, Regenerative Medicine, Stem Cell Research, Generic Health Relevance, 1.1 Normal biological development and functioning
Gatsby Charitable Foundation (GAT3395-PR4)
Gatsby Charitable Foundation (unknown)
Gatsby Charitable Foundation (GAT3395/PR4)
External DOI: https://doi.org/10.1038/s41540-018-0072-1
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285149
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/
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