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dc.contributor.authorDrion, Guillaume
dc.contributor.authorFranci, Alessio
dc.contributor.authorSepulchre, Rodolphe
dc.date.accessioned2018-11-17T00:31:37Z
dc.date.available2018-11-17T00:31:37Z
dc.date.issued2019-04
dc.identifier.issn0340-1200
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285374
dc.description.abstractSmall inhibitory neuronal circuits have long been identified as key neuronal motifs to generate and modulate the coexisting rhythms of various motor functions. Our paper highlights the role of a cellular switching mechanism to orchestrate such circuits. The cellular switch makes the circuits reconfigurable, robust, adaptable, and externally controllable. Without this cellular mechanism, the circuit rhythms entirely rely on specific tunings of the synaptic connectivity, which makes them rigid, fragile, and difficult to control externally. We illustrate those properties on the much studied architecture of a small network controlling both the pyloric and gastric rhythms of crabs. The cellular switch is provided by a slow negative conductance often neglected in mathematical modeling of central pattern generators. We propose that this conductance is simple to model and key to computational studies of rhythmic circuit neuromodulation.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.subjectNerve Net
dc.subjectNeurons
dc.subjectAnimals
dc.subjectBrachyura
dc.subjectPeriodicity
dc.subjectAction Potentials
dc.subjectNonlinear Dynamics
dc.subjectModels, Neurological
dc.subjectComputer Simulation
dc.titleCellular switches orchestrate rhythmic circuits.
dc.typeArticle
prism.endingPage82
prism.issueIdentifier1-2
prism.publicationDate2019
prism.publicationNameBiol Cybern
prism.startingPage71
prism.volume113
dc.identifier.doi10.17863/CAM.32740
dcterms.dateAccepted2018-08-20
rioxxterms.versionofrecord10.1007/s00422-018-0778-6
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-04
dc.contributor.orcidDrion, Guillaume [0000-0002-8076-9500]
dc.contributor.orcidSepulchre, Rodolphe [0000-0002-7047-3124]
dc.identifier.eissn1432-0770
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Research Council (670645)
cam.issuedOnline2018-09-03
rioxxterms.freetoread.startdate2019-09-03


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