Diastereoselective C-H carbonylative annulation of aliphatic amines: a rapid route to functionalized γ-lactams.
| dc.contributor.author | Png, Zhuang Mao | |
| dc.contributor.author | Cabrera-Pardo, Jaime R | |
| dc.contributor.author | Peiró Cadahía, Jorge | |
| dc.contributor.author | Gaunt, Matthew J | |
| dc.date.accessioned | 2018-11-22T00:31:59Z | |
| dc.date.available | 2018-11-22T00:31:59Z | |
| dc.date.issued | 2018-10-21 | |
| dc.identifier.issn | 2041-6520 | |
| dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/285642 | |
| dc.description.abstract | A palladium(ii)-catalysed C(sp3)-H carbonylation of free(NH) secondary aliphatic amines to 2-pyrrolidinones is described. A correlation between the nature of the carboxylate ligand and the diastereoselectivity and yield of the process was observed. As such, under these optimal conditions a range of aliphatic amines were converted to the corresponding trans-4,5-disubstituted 2-pyrrolidines with good d.r. and yield. | |
| dc.description.sponsorship | EPSRC (EP/N031792/1) Royal Society (Wolfson Award) Agency for Science Technology and Research (A*STAR, Singapore) H2020-MSCA for an International Incoming Fellowship | |
| dc.format.medium | Electronic-eCollection | |
| dc.language | eng | |
| dc.publisher | Royal Society of Chemistry (RSC) | |
| dc.rights | Attribution 4.0 International | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.title | Diastereoselective C-H carbonylative annulation of aliphatic amines: a rapid route to functionalized γ-lactams. | |
| dc.type | Article | |
| prism.endingPage | 7633 | |
| prism.issueIdentifier | 39 | |
| prism.publicationDate | 2018 | |
| prism.publicationName | Chem Sci | |
| prism.startingPage | 7628 | |
| prism.volume | 9 | |
| dc.identifier.doi | 10.17863/CAM.32994 | |
| dcterms.dateAccepted | 2018-07-20 | |
| rioxxterms.versionofrecord | 10.1039/c8sc02855a | |
| rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
| rioxxterms.licenseref.startdate | 2018-10 | |
| dc.contributor.orcid | Gaunt, Matthew J [0000-0002-7214-608X] | |
| dc.identifier.eissn | 2041-6539 | |
| rioxxterms.type | Journal Article/Review | |
| pubs.funder-project-id | Engineering and Physical Sciences Research Council (EP/N031792/1) | |
| pubs.funder-project-id | The Royal Society (wm140104) | |
| pubs.funder-project-id | European Commission (655856) | |
| cam.issuedOnline | 2018-07-31 |
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