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dc.contributor.authorPng, Zhuang Mao
dc.contributor.authorCabrera-Pardo, Jaime R
dc.contributor.authorPeiró Cadahía, Jorge
dc.contributor.authorGaunt, Matthew J
dc.date.accessioned2018-11-22T00:31:59Z
dc.date.available2018-11-22T00:31:59Z
dc.date.issued2018-10-21
dc.identifier.issn2041-6520
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285642
dc.description.abstractA palladium(ii)-catalysed C(sp3)-H carbonylation of free(NH) secondary aliphatic amines to 2-pyrrolidinones is described. A correlation between the nature of the carboxylate ligand and the diastereoselectivity and yield of the process was observed. As such, under these optimal conditions a range of aliphatic amines were converted to the corresponding trans-4,5-disubstituted 2-pyrrolidines with good d.r. and yield.
dc.description.sponsorshipEPSRC (EP/N031792/1) Royal Society (Wolfson Award) Agency for Science Technology and Research (A*STAR, Singapore) H2020-MSCA for an International Incoming Fellowship
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherRoyal Society of Chemistry (RSC)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleDiastereoselective C-H carbonylative annulation of aliphatic amines: a rapid route to functionalized γ-lactams.
dc.typeArticle
prism.endingPage7633
prism.issueIdentifier39
prism.publicationDate2018
prism.publicationNameChem Sci
prism.startingPage7628
prism.volume9
dc.identifier.doi10.17863/CAM.32994
dcterms.dateAccepted2018-07-20
rioxxterms.versionofrecord10.1039/c8sc02855a
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-10
dc.contributor.orcidGaunt, Matthew J [0000-0002-7214-608X]
dc.identifier.eissn2041-6539
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/N031792/1)
pubs.funder-project-idThe Royal Society (wm140104)
pubs.funder-project-idEuropean Commission (655856)
cam.issuedOnline2018-07-31


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International