Show simple item record

dc.contributor.authorBrady, Ryan
dc.contributor.authorBrooks, Nicholas
dc.contributor.authorFodara, Vito
dc.contributor.authorCicuta, Pietro
dc.contributor.authorDi Michele, Lorenzo
dc.date.accessioned2018-11-24T00:31:34Z
dc.date.available2018-11-24T00:31:34Z
dc.date.issued2018-11-14
dc.identifier.issn1520-5126
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285953
dc.description.abstractThe reliable preparation of functional, ordered, nanostructured frameworks would be a game changer for many emerging technologies, from energy storage to nanomedicine. Underpinned by the excellent molecular recognition of nucleic acids, along with their facile synthesis and breadth of available functionalizations, DNA Nanotechnology is widely acknowledged as a prime route for the rational design of nanostructured materials. Yet, the preparation of crystalline DNA frameworks with programmable structure and functionality remains a challenge. Here we demonstrate the potential of simple amphiphilic DNA motifs, dubbed C-stars, as a versatile platform for the design of programmable DNA crystals. In contrast to all-DNA materials, in which structure depends on the precise molecular details of individual build-ing blocks, the self-assembly of C-stars is controlled uniquely by their topology and symmetry. Exploiting this robust self-assembly principle we design a range of topologically identical, but structurally and chemically distinct C-stars that following a one-pot reaction self- assemble into highly porous, functional, crystalline frameworks. Simple design variations allow us to fine-tune the lattice parameter and thus control the partitioning of macromolecules within the frameworks, embed responsive motifs that can induce isothermal disassembly, and include chemical moieties to capture target proteins specifically and reversibly.
dc.description.sponsorshipLDM, PC and NJB acknowledge support from the EPSRC Programme Grant CAPITALS number EP/J017566/1. LDM acknowledges support from the Leverhulme Trust and the Isaac Newton Trust through an Early Career Fellow- 9 ship (ECF-2015-494) and from the Royal Society through a University Research Fellowship (UF160152). RAB acknowledges support from the EPSRC CDT in Nanoscience and Nanotechnology (NanoDTC), grant number EP/L015978/1.
dc.publisherAmerican Chemical Society (ACS)
dc.titleAn amphiphilic-DNA platform for the design of crystalline frameworks with programmable structure and functionality
dc.typeArticle
prism.publicationNameJournal of the American Chemical Society
dc.identifier.doi10.17863/CAM.33280
dcterms.dateAccepted2018-10-23
rioxxterms.versionofrecord10.1021/jacs.8b09143
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-10-23
dc.contributor.orcidCicuta, Pietro [0000-0002-9193-8496]
dc.contributor.orcidDi Michele, Lorenzo [0000-0002-1458-9747]
dc.identifier.eissn1520-5126
rioxxterms.typeJournal Article/Review
pubs.funder-project-idLeverhulme Trust (ECF-2015-494)
pubs.funder-project-idIsaac Newton Trust (MIN 1508(S))
pubs.funder-project-idRoyal Society (UF160152)
pubs.funder-project-idRoyal Society (RGF/R1/180043)
pubs.funder-project-idEPSRC (via Imperial College London) (CHIS_P39012)
pubs.funder-project-idEPSRC (1494571)
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/L015978/1)
cam.issuedOnline2018-10-23
rioxxterms.freetoread.startdate2019-10-23


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record