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dc.contributor.authorJauniaux, Eric
dc.contributor.authorBurton, Graham
dc.date.accessioned2018-11-24T00:31:41Z
dc.date.available2018-11-24T00:31:41Z
dc.date.issued2018-12
dc.identifier.issn0009-9201
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285957
dc.description.abstractCurrent findings continue to support the concept of a biologically defective decidua rather than a primarily abnormally invasive trophoblast. Prior cesarean sections increase the risk of placenta previa and both adherent and invasive placenta accreta, suggesting that the endometrial/decidual defect following the iatrogenic creation of a uterine myometrium scar has an adverse effect on early implantation. Preferential attachment of the blastocyst to scar tissue facilitates abnormally deep invasion of trophoblastic cells and interactions with the radial and arcuate arteries. Subsequent high velocity maternal arterial inflow into the placenta creates large lacunae, destroying the normal cotyledonary arrangement of the villi.
dc.format.mediumPrint
dc.languageeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.subjectMyometrium
dc.subjectDecidua
dc.subjectCicatrix
dc.subjectTrophoblasts
dc.subjectHumans
dc.subjectPlacenta Accreta
dc.subjectUltrasonography, Prenatal
dc.subjectCesarean Section
dc.subjectPregnancy
dc.subjectPlacental Circulation
dc.subjectFemale
dc.subjectPlacenta Previa
dc.subjectUterine Artery
dc.titlePathophysiology of Placenta Accreta Spectrum Disorders: A Review of Current Findings.
dc.typeArticle
prism.endingPage754
prism.issueIdentifier4
prism.publicationDate2018
prism.publicationNameClin Obstet Gynecol
prism.startingPage743
prism.volume61
dc.identifier.doi10.17863/CAM.33284
rioxxterms.versionofrecord10.1097/GRF.0000000000000392
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-12
dc.contributor.orcidBurton, Graham [0000-0001-8677-4143]
dc.identifier.eissn1532-5520
rioxxterms.typeJournal Article/Review
rioxxterms.freetoread.startdate2019-12-31


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