RNA modifications modulate gene expression during development.
American Association for the Advancement of Science (AAAS)
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Frye, M., Harada, B. T., Behm, M., & He, C. (2018). RNA modifications modulate gene expression during development.. Science, 361 (6409), 1346-1349. https://doi.org/10.1126/science.aau1646
RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programs. They affect diverse eukaryotic biological processes, and the correct deposition of many of these modifications is required for normal development. Messenger RNA (mRNA) modifications regulate various aspects of mRNA metabolism. For example, N 6-methyladenosine (m6A) affects the translation and stability of the modified transcripts, thus providing a mechanism to coordinate the regulation of groups of transcripts during cell state maintenance and transition. Similarly, some modifications in transfer RNAs are essential for RNA structure and function. Others are deposited in response to external cues and adapt global protein synthesis and gene-specific translational accordingly and thereby facilitate proper development.
Animals, Humans, Mice, Disease, Methyltransferases, RNA, Messenger, RNA, Ribosomal, RNA, Transfer, Adenosine, Cell Differentiation, Transcription, Genetic, Gene Expression Regulation, Developmental, RNA Processing, Post-Transcriptional
B.T.H is supported by National Cancer Institute fellowship F32 CA221007. C.H. is supported by National Institute of Health (HG008935 and GM071440). C.H. is an investigator of the Howard Hughes Medical Institute. M.F. is supported by a Cancer Research UK Senior Fellowship (C10701/A15181), the European Research Council (ERC; 310360), and the Medical Research Council UK (MR/M01939X/1). Part of this work was carried out in the framework of the European COST action EPITRAN 16120.
Medical Research Council (MC_PC_12009)
Medical Research Council (MR/M01939X/1)
European Research Council (310360)
External DOI: https://doi.org/10.1126/science.aau1646
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286245