A track of the clones: new developments in cellular barcoding.
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Lyne, A., Kent, D., Laurenti, E., Cornils, K., Glauche, I., & Perié, L. (2018). A track of the clones: new developments in cellular barcoding.. Exp Hematol, 68 15-20. https://doi.org/10.1016/j.exphem.2018.11.005
International experts from multiple disciplines gathered at Homerton College in Cambridge, UK from September 12-14, 2018 to consider recent advances and emerging opportunities in the clonal tracking of hematopoiesis in one of a series of StemCellMathLab workshops. The group included 35 participants with experience in the fields of theoretical and experimental aspects of clonal tracking, and ranged from doctoral students to senior professors. Data from a variety of model systems and from clinical gene therapy trials were discussed, along with strategies for data analysis and sharing and challenges arising due to underlying assumptions in data interpretation and communication. Recognizing the power of this technology underpinned a group consensus of a need for improved mechanisms for sharing data and analytical protocols to maintain reproducibility and rigor in its application to complex tissues.
Clone Cells, Stem Cells, DNA Transposable Elements, Genetic Markers, Cell Separation, Reproducibility of Results, Data Display, Virus Integration, Hematopoiesis, Cell Lineage, Mosaicism, Models, Biological, Research Design, Forecasting, Clinical Trials as Topic, Guidelines as Topic, DNA Barcoding, Taxonomic, Cell Tracking, Genetic Therapy
We thank the BBSRC (BB/R021465/1), the German Stem Cell Network, the Wellcome-MRC Cambridge Stem Cell Institute and the Labex CelTisPhyBio (No. ANR-10-LBX-0038) for funds to support this workshop and the conference staff at Homerton College
Biotechnology and Biological Sciences Research Council (BB/R021465/1)
Medical Research Council (MC_PC_12009)
European Research Council (715371)
External DOI: https://doi.org/10.1016/j.exphem.2018.11.005
This record's URL: https://www.repository.cam.ac.uk/handle/1810/287061