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dc.contributor.authorMurphy, Michael P
dc.contributor.authorO'Neill, Luke AJ
dc.date.accessioned2018-12-18T00:32:29Z
dc.date.available2018-12-18T00:32:29Z
dc.date.issued2018-08-09
dc.identifier.issn0092-8674
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/287097
dc.description.abstractKrebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. It is now clear that some of these metabolites also act as signals. Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role.
dc.format.mediumPrint
dc.languageeng
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAnimals
dc.subjectHumans
dc.subjectSuccinic Acid
dc.subjectSuccinates
dc.subjectSignal Transduction
dc.subjectCitric Acid Cycle
dc.titleKrebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.
dc.typeArticle
prism.endingPage784
prism.issueIdentifier4
prism.publicationDate2018
prism.publicationNameCell
prism.startingPage780
prism.volume174
dc.identifier.doi10.17863/CAM.34407
dcterms.dateAccepted2018-07-23
rioxxterms.versionofrecord10.1016/j.cell.2018.07.030
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-08
dc.contributor.orcidMurphy, Mike [0000-0003-1115-9618]
dc.identifier.eissn1097-4172
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_00015/3)
pubs.funder-project-idWellcome Trust (110159/Z/15/Z)
pubs.funder-project-idMedical Research Council (MC_UU_00015/8)
pubs.funder-project-idMRC (MC_UU_00015/8)
rioxxterms.freetoread.startdate2019-08-09


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International