Ten things you should know about transposable elements.
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Authors
Burns, Kathleen H
Gehring, Mary
Gorbunova, Vera
Seluanov, Andrei
Hammell, Molly
Imbeault, Michaël
Izsvák, Zsuzsanna
Levin, Henry L
Macfarlan, Todd S
Mager, Dixie L
Feschotte, Cédric
Publication Date
2018-11-19Journal Title
Genome Biol
ISSN
1474-7596
Publisher
Springer Science and Business Media LLC
Volume
19
Issue
1
Pages
199
Language
eng
Type
Article
This Version
VoR
Physical Medium
Electronic
Metadata
Show full item recordCitation
Bourque, G., Burns, K. H., Gehring, M., Gorbunova, V., Seluanov, A., Hammell, M., Imbeault, M., et al. (2018). Ten things you should know about transposable elements.. Genome Biol, 19 (1), 199. https://doi.org/10.1186/s13059-018-1577-z
Abstract
Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities of TEs and implies that they should no longer be marginalized. Here, we introduce the fundamental properties of TEs and their complex interactions with their cellular environment, which are crucial to understanding their impact and manifold consequences for organismal biology. While we draw examples primarily from mammalian systems, the core concepts outlined here are relevant to a broad range of organisms.
Keywords
Animals, Humans, DNA Transposable Elements, Gene Rearrangement, Mutation, Polymorphism, Genetic
Identifiers
External DOI: https://doi.org/10.1186/s13059-018-1577-z
This record's URL: https://www.repository.cam.ac.uk/handle/1810/287157
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