Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs.
Int J Nanomedicine
Informa UK Limited
MetadataShow full item record
Accardo, A., Aloj, L., Aurilio, M., Morelli, G., & Tesauro, D. (2014). Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs.. Int J Nanomedicine, 9 1537-1557. https://doi.org/10.2147/IJN.S53593
Active targeting by means of drug encapsulated nanoparticles decorated with targeting bioactive moieties represents the next frontier in drug delivery; it reduces drug side effects and increases the therapeutic index. Peptides, based on their chemical and biological properties, could have a prevalent role to direct drug encapsulated nanoparticles, such as liposomes, micelles, or hard nanoparticles, toward the tumor tissues. A considerable number of molecular targets for peptides are either exclusively expressed or overexpressed on both cancer vasculature and cancer cells. They can be classified into three wide categories: integrins; growth factor receptors (GFRs); and G-protein coupled receptors (GPCRs). Therapeutic agents based on nanovectors decorated with peptides targeting membrane receptors belonging to the GPCR family overexpressed by cancer cells are reviewed in this article. The most studied targeting membrane receptors are considered: somatostatin receptors; cholecystokinin receptors; receptors associated with the Bombesin like peptides family; luteinizing hormone-releasing hormone receptors; and neurotensin receptors. Nanovectors of different sizes and shapes (micelles, liposomes, or hard nanoparticles) loaded with doxorubicin or other cytotoxic drugs and externally functionalized with natural or synthetic peptides are able to target the overexpressed receptors and are described based on their formulation and in vitro and in vivo behaviors.
active targeting, drug delivery, nanoparticles, receptors binding peptides, supramolecular aggregates, Animals, Antineoplastic Agents, Humans, Molecular Targeted Therapy, Nanocapsules, Neoplasms, Peptides, Receptors, Peptide
External DOI: https://doi.org/10.2147/IJN.S53593
This record's URL: https://www.repository.cam.ac.uk/handle/1810/287414
Attribution-NonCommercial 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc/4.0/
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: email@example.com