Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder.
Fonzo, Gregory A
Goodkind, Madeleine S
Peng, Kathy K
Rothbaum, Barbara O
Marmar, Charles R
Sci Transl Med
American Association for the Advancement of Science (AAAS)
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Etkin, A., Maron-Katz, A., Wu, W., Fonzo, G. A., Huemer, J., Vértes, P. E., Patenaude, B., et al. (2019). Using fMRI connectivity to define a treatment-resistant form of post-traumatic stress disorder.. Sci Transl Med, 11 (486) https://doi.org/10.1126/scitranslmed.aal3236
A mechanistic understanding of the pathology of psychiatric disorders has been hampered by extensive heterogeneity in biology, symptoms, and behavior within diagnostic categories that are defined subjectively. We investigated whether leveraging individual differences in information-processing impairments in patients with post-traumatic stress disorder (PTSD) could reveal phenotypes within the disorder. We found that a subgroup of patients with PTSD from two independent cohorts displayed both aberrant functional connectivity within the ventral attention network (VAN) as revealed by functional magnetic resonance imaging (fMRI) neuroimaging and impaired verbal memory on a word list learning task. This combined phenotype was not associated with differences in symptoms or comorbidities, but nonetheless could be used to predict a poor response to psychotherapy, the best-validated treatment for PTSD. Using concurrent focal noninvasive transcranial magnetic stimulation and electroencephalography, we then identified alterations in neural signal flow in the VAN that were evoked by direct stimulation of that network. These alterations were associated with individual differences in functional fMRI connectivity within the VAN. Our findings define specific neurobiological mechanisms in a subgroup of patients with PTSD that could contribute to the poor response to psychotherapy.
Nerve Net, Humans, Magnetic Resonance Imaging, Electroencephalography, Treatment Outcome, Brain Mapping, Behavior, Mental Recall, Attention, Stress Disorders, Post-Traumatic, Comorbidity, Rest, Transcranial Magnetic Stimulation
PEV was supported by the Medical Research Council (grant no. MR/K020706/1) and is a Fellow of MQ: Transforming Mental Health (MQF17_24).
Medical Research Council (MR/K020706/1)
MQ: Transforming Mental Health (MQ17-24 Vertes)
External DOI: https://doi.org/10.1126/scitranslmed.aal3236
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288149