Circulating Tumor Cells: Come Together, Right Now, Over Metastasis.
American Association for Cancer Research (AACR)
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Rodrigues, P., & Vanharanta, S. (2019). Circulating Tumor Cells: Come Together, Right Now, Over Metastasis.. Cancer Discov, 9 (1), 22-24. https://doi.org/10.1158/2159-8290.CD-18-1285
Circulating tumor cells (CTC) are the source of metastases, but only an infinitesimal fraction of them eventually succeed in colonizing a distant organ. New results show that CD44-dependent aggregation in the circulation provides CTCs with cancer stem cell-like characteristics, suggesting an explanation for the low metastatic efficiency of CTCs, but also avenues for therapeutic intervention.See related article by Liu et al., p. 96.
Humans, Breast Neoplasms, Cell Aggregation, Neoplastic Stem Cells, Neoplastic Cells, Circulating, Hyaluronan Receptors
Medical Research Council (MC_UU_12022/7)
External DOI: https://doi.org/10.1158/2159-8290.CD-18-1285
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288167