An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo
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Proctor, C., Uguz, I., Slezia, A., Curto, V., Inal, S., Williamson, A., & Malliaras, G. (2019). An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo. Advanced Biosystems, 3 (2. 1800270) https://doi.org/10.1002/adbi.201800270
The challenge of treating neurological disorders has motivated the development of implantable devices that can deliver treatment when and where it’s needed. This study presents a novel brain implant capable of electrophoretically delivering drugs and recording local neural activity on the surface of the brain. The drug delivery is made possible by the integration of a microfluidic ion pump (µFIP) into a conformable electrocorticography (ECoG) device with recording cites embedded next to the drug delivery outlets. The µFIP ECoG device can deliver a high capacity of several biologically important cationic species on demand. The therapeutic potential of the device is demonstrated by using it to deliver neurotransmitters in a rodent model while simultaneously recording local neural activity. These developments represent a signiﬁcant step forward for cortical drug-delivery systems.
External DOI: https://doi.org/10.1002/adbi.201800270
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288168