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dc.contributor.authorBogdan, Michalen
dc.contributor.authorSavin, Thierryen
dc.date.accessioned2019-01-18T00:31:50Z
dc.date.available2019-01-18T00:31:50Z
dc.date.issued2018-12-19en
dc.identifier.issn2054-5703
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/288192
dc.description.abstractMetastatic tumours often invade healthy neighbouring tissues by forming multicellular finger-like protrusions emerging from the cancer mass. To understand the mechanical context behind this phenomenon, we here develop a minimalist fluid model of a self-propelled, growing biological tissue. The theory involves only four mechanical parameters and remains analytically trackable in various settings. As an application of the model, we study the evolution of a 2D circular droplet made of our active and expanding fluid, and embedded in a passive non-growing tissue. This system could be used to model the evolution of a carcinoma in an epithelial layer. We find that our description can explain the propensity of tumour tissues to fingering instabilities, as conditioned by both the magnitude of active traction and the growth kinetics. We are also able to derive predictions for the tumour size at the onset of metastasis, and for the number of subsequent invasive fingers. Our active fluid model may help describe a wider range of biological processes, including wound healing and developmental patterning.
dc.format.mediumElectronic-eCollectionen
dc.languageengen
dc.publisherThe Royal Society
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleFingering instabilities in tissue invasion: an active fluid model.en
dc.typeArticle
prism.issueIdentifier12en
prism.publicationDate2018en
prism.publicationNameRoyal Society open scienceen
prism.startingPage181579
prism.volume5en
dc.identifier.doi10.17863/CAM.35508
dcterms.dateAccepted2018-11-20en
rioxxterms.versionofrecord10.1098/rsos.181579en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-12-19en
dc.contributor.orcidSavin, Thierry [0000-0002-3956-7077]
dc.identifier.eissn2054-5703
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEPSRC (1623841)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International