The First Norovirus Longitudinal Seroepidemiological Study From Sub-Saharan Africa Reveals High Seroprevalence of Diverse Genotypes Associated With Host Susceptibility Factors.

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Authors
  Thorne, Lucy
  Nalwoga, Angela
  Mentzer, Alexander J
  de Rougemont, Alexis
  Hosmillo, Myra
Webb, Emily
Nampiija, Margaret
Publication Date
2018-07
Journal Title
The Journal of infectious diseases
ISSN
0022-1899
Publisher
University of Chicago Press
Volume
218
Issue
5
Pages
716-725
Language
eng
Type
Article
This Version
VoR
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Physical Medium
Print
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Citation
Thorne, L., Nalwoga, A., Mentzer, A. J., de Rougemont, A., Hosmillo, M., Webb, E., Nampiija, M., et al. (2018). The First Norovirus Longitudinal Seroepidemiological Study From Sub-Saharan Africa Reveals High Seroprevalence of Diverse Genotypes Associated With Host Susceptibility Factors.. The Journal of infectious diseases, 218 (5), 716-725. https://doi.org/10.1093/infdis/jiy219
Abstract
Human noroviruses (HuNoVs) are a prominent cause of gastroenteritis, yet fundamental questions remain regarding epidemiology, diversity and immunity in sub-­Saharan African children. We investigated HuNoV seroprevalence and genetic and sociodemographic risk factors in Ugandan children.
Keywords
Humans, Norovirus, Caliciviridae Infections, Gastroenteritis, Disease Susceptibility, Fucosyltransferases, Antibodies, Viral, Blood Group Antigens, Enzyme-Linked Immunosorbent Assay, Risk Factors, Longitudinal Studies, Cross-Sectional Studies, Seroepidemiologic Studies, Demography, Pregnancy, Genotype, Polymorphism, Single Nucleotide, Socioeconomic Factors, Child, Preschool, Infant, Infant, Newborn, Uganda, Female, Male, Genetic Variation
Sponsorship
Wellcome Trust (097997/Z/11/Z)
MRC (MR/K013491/1)
Wellcome Trust Sanger Institute, Genome Research Limited (S0818)
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1093/infdis/jiy219
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288248

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Attribution 4.0 International
Licence URL: http://creativecommons.org/licenses/by/4.0/


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International