Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study
International Journal of Epidemiology
Oxford University Press
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Easton, D. (2018). Circulating vitamin D concentrations and risk of breast and prostate cancer: a Mendelian randomization study. International Journal of Epidemiology https://doi.org/10.1093/ije/dyy284
Background: Observational studies have suggested an association between circulating vitamin D concentrations [25(OH)D] and risk of breast and prostate cancer, which was not supported by a recent Mendelian randomization analysis comprising 15,748 breast and 22,898 prostate cancer cases. Demonstrating causality has proven challenging, and one common limitation of MR studies is insufficient power. Methods: We aim to determine if circulating concentrations of vitamin D are causally associated with the risk of breast and prostate cancer, by using summary level data from the largest-ever genome-wide association studies conducted on vitamin D (N=73,699), breast cancer (Ncase=122,977) and prostate cancer (Ncase=79,148). We constructed a stronger instrument using six common genetic variants (as compared with the previous four variants), and applied several two-sample MR methods.
This work was supported by the Veteskapsrådet International Postdoc grant (XJ), the World Cancer Research Fund International Regular Grant Programme (WCRF 2014/1180) (KKT), the World Cancer Research Fund International grant (WCRF 2015/1421) (SL), the National Cancer Institute Grant (R00 CA207848) (SWA), the Cancer Research UK Programme Grant, the Integrative Cancer Epidemiology Programme (C18281/A19169) (RMM), and the National Institute for Health Research (NIHR) Bristol Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol.
External DOI: https://doi.org/10.1093/ije/dyy284
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288569