Force-based three-dimensional model predicts mechanical drivers of cell sorting.
Proceedings. Biological sciences
The Royal Society
MetadataShow full item record
Revell, C., Blumenfeld, R., & Chalut, K. (2019). Force-based three-dimensional model predicts mechanical drivers of cell sorting.. Proceedings. Biological sciences, 286 (1895), 20182495. https://doi.org/10.1098/rspb.2018.2495
Many biological processes, including tissue morphogenesis, are driven by cell sorting. However, in part because there is no appropriate computational model to probe mechanical interactions between cells, the primary mechanical drivers of sorting in multicellular aggregates remain controversial. To address this important issue, we developed a three-dimensional, local force-based simulation based on the subcellular element method. In our method, cells are modeled as collections of locally-interacting force-bearing elements. We use the method to investigate the effects of tension and cell-cell adhesion on multicellular aggregate sorting. We predict a minimum level of adhesion to produce inside-out sorting of two cell types, which is in excellent agreement with observations in several developmental systems. We also predict the level of tension asymmetry needed for robust sorting. The generality and flexibility of the method make it applicable to tissue self-organization in a myriad of other biological processes, such as tumorigenesis and embryogenesis.
Cell Movement, Embryonic Development, Models, Biological, Computer Simulation, Carcinogenesis
This work was financially supported by the Medical Research Council and the Wellcome Trust. KC is a University Research Fellow of the Royal Society, which also provided financial support for this work
External DOI: https://doi.org/10.1098/rspb.2018.2495
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288720
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/