Synthesis of riboflavines, quinoxalinones and benzodiazepines through chemoselective flow based hydrogenations.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Baumann, Marcus
Baxendale, Ian R
Hornung, Christian H
Ley, Steven V
Rojo, Maria Victoria
Abstract
Robust chemical routes towards valuable bioactive entities such as riboflavines, quinoxalinones and benzodiazepines are described. These make use of modern flow hydrogenation protocols enabling the chemoselective reduction of nitro group containing building blocks in order to rapidly generate the desired amine intermediates in situ. In order to exploit the benefits of continuous processing the individual steps were transformed into a telescoped flow process delivering selected benzodiazepine products on scales of 50 mmol and 120 mmol respectively.
Description
Keywords
Benzodiazepines, Hydrogenation, Riboflavin
Journal Title
Molecules
Conference Name
Journal ISSN
1420-3049
1420-3049
1420-3049
Volume Title
19
Publisher
MDPI AG