Data regarding transplant induced germinal center humoral autoimmunity.
Qureshi, M Saeed
Ali, Jason M
Goddard, Martin J
Data in brief
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Qureshi, M. S., Alsughayyir, J., Chhabra, M., Ali, J. M., Goddard, M. J., Devine, C., Conlon, T. M., et al. (2019). Data regarding transplant induced germinal center humoral autoimmunity.. Data in brief, 22 647-657. https://doi.org/10.1016/j.dib.2018.12.078
© 2019 The Authors This data is related to the research article entitled “Germinal center humoral autoimmunity independently mediates progression of allograft vasculopathy” (Harper et al., 2016) . The data presented here focuses on the humoral autoimmune response triggered by transferred allogeneic CD4 T cells and includes details on: (a) the recipient splenic germinal center (GC) response; (b) augmentation of humoral autoimmunity and accelerated heart allograft rejection following transplantation from donors primed against recipient; (c) flow cytometric analysis of donor and recipient CD4 T cells for signature markers of T follicular helper cell differentiation; (d) in vitro donor endothelial cell migration in response to column purified autoantibody from recipient sera; (e) analysis of development of humoral responses in recipients following adoptive transfer of donor CD4 T cells and; (f) the development of humoral autoimmunity in mixed haematopoietic chimeric mice.
British Heart Foundation
Wellcome Trust (096207/Z/11/Z)
British Heart Foundation (FS/12/87/29899)
External DOI: https://doi.org/10.1016/j.dib.2018.12.078
This record's URL: https://www.repository.cam.ac.uk/handle/1810/289010
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/