Parallel adaptation of rabbit populations to myxoma virus.
Cheng, Jade Y
Rahman, Masmudur M
Bell, Diana J
Palmer, William J
Surridge, Alison K
Science (New York, N.Y.)
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Alves, J. M., Carneiro, M., Cheng, J. Y., Lemos de Matos, A., Rahman, M. M., Loog, L., Campos, P. F., et al. (2019). Parallel adaptation of rabbit populations to myxoma virus.. Science (New York, N.Y.), 363 (6433), 1319-1326. https://doi.org/10.1126/science.aau7285
In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution across Australia, France and the United Kingdom, with selection acting on standing genetic variation and the same alleles changing in frequency over the last 60 years. These changes occurred in immunity-related genes and support a polygenic basis of resistance. We experimentally validated the role of these genes and showed that selection acting on an interferon protein has increased its antiviral effect.
Animals, Rabbits, Myxoma virus, Myxomatosis, Infectious, Adaptation, Biological, Evolution, Molecular, Gene Frequency, Polymorphism, Single Nucleotide, Alleles, Population, Australia, France, Immunity, Innate, Genetic Variation, United Kingdom, Interferon alpha-2
This work was supported by grants from the Programa Operacional Potencial Humano–Quadro de Referência Estratégica Nacional funds from the European Social Fund and Portuguese Ministério da Ciência, Tecnologia e Ensino Superior to M.C. (IF/00283/2014/CP1256/CT0012), to P.J.E. (IF/00376/2015) and to J.M.A. (SFRH/BD/72381/2010). AM was supported by the European Research Council (grant 647787-LocalAdaptation). FJ was supported by the European Research Council (grant 281668). LL was supported by the European Research Council grant (339941-ADAPT). McFadden Lab is supported by National Institute of Health (NIH) grant R01 AI080607. S.C.G. holds a Sir Henry Dale Fellowship, co-funded by the Wellcome Trust and the Royal Society (098406/Z/12/Z).
European Research Council (281668)
Wellcome Trust (098406/Z/12/B)
ECH2020 EUROPEAN RESEARCH COUNCIL (ERC) (647787)
Wellcome Trust (098406/Z/12/Z)
External DOI: https://doi.org/10.1126/science.aau7285
This record's URL: https://www.repository.cam.ac.uk/handle/1810/289357