Diversity in the oligodendrocyte lineage: Plasticity or heterogeneity?
John Wiley & Sons Inc.
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Foerster, S., Hill, M., & Franklin, R. (2019). Diversity in the oligodendrocyte lineage: Plasticity or heterogeneity?. Glia, 67 (10), 1797-1805. https://doi.org/10.1002/glia.23607
Heterogeneity is a widely recognised phenomenon within the majority of cell types in the body including cells of the central nervous system (CNS). The heterogeneity of neurons based on their distinct transmission modes and firing patterns has been recognised for decades, and is necessary to coordinate the immense variety of functions of the CNS. More recently, heterogeneity in glial cells has been described, including heterogeneity in oligodendrocyte progenitor cells (OPCs) and oligodendrocytes. OPC subpopulations have been described based on their developmental origin, anatomical location in the grey or white matter, and expression of surface receptors. Oligodendrocytes are categorised according to differences in gene expression, myelinogenic potential and axon specificity. Much of what is described as heterogeneity in oligodendrocyte lineage cells (OLCs) is based on phenotypic differences. However, without evidence for functional differences between putative subgroups of oligodendrocyte lineage cells (OLCs), distinguishing heterogeneity from plasticity and lineage state is difficult. Identifying functional differences between phenotypically distinct groups is therefore necessary for a deeper understanding of the role of OLCs in health and disease.
Central Nervous System, Oligodendroglia, Animals, Cell Lineage, Oligodendrocyte Precursor Cells
The authors acknowledge the support of funding from the UK Multiple Sclerosis Society, MedImmune, The Adelson Medical Research Foundation and a core support grant from the Wellcome Trust and MRC to the Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. SF and MFEH have been recipients of Wellcome Trust funded PhD studentships.
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External DOI: https://doi.org/10.1002/glia.23607
This record's URL: https://www.repository.cam.ac.uk/handle/1810/290070