Antibiotic Resistance and Typhoid.
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Peer-reviewed
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Abstract
Multiple drug (antibiotic) resistance (MDR) has become a major threat to the treatment of typhoid and other infectious diseases. Since the 1970s, this threat has increased in Salmonella enterica serovar Typhi, driven in part by the emergence of successful genetic clades, such as haplotype H58, associated with the MDR phenotype. H58 S. Typhi can express multiple antibiotic resistance determinants while retaining the ability to efficiently transmit and persist within the human population. The recent identification of extensively drug resistant S. Typhi only highlights the dangers of ignoring this threat. Here we discuss the evolution of the S. Typhi MDR phenotype and consider options for management.
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Keywords
S. Typhi, H58, MDR, multiple drug resistance, typhoid, Anti-Bacterial Agents, Disease Management, Drug Resistance, Multiple, Bacterial, Evolution, Molecular, Haplotypes, Humans, Microbial Sensitivity Tests, Phylogeny, Plasmids, Salmonella typhi, Typhoid Fever, Whole Genome Sequencing
Journal Title
Clin Infect Dis
Conference Name
Journal ISSN
1058-4838
1537-6591
1537-6591
Volume Title
68
Publisher
Oxford University Press (OUP)
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Sponsorship
Bill & Melinda Gates Foundation (via University of Oxford) (unknown)
Cambridge University Hospitals NHS Foundation Trust (CUH) (BRC)
Cambridge University Hospitals NHS Foundation Trust (CUH) (BRC)