Immunophenotypes of pancreatic ductal adenocarcinoma: Meta-analysis of transcriptional subtypes.
de Santiago, Ines
Middleton, Mark R
Grabsch, Heike I
Dustin, Michael L
International Journal of Cancer
John Wiley & Sons Inc.
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de Santiago, I., Yau, C., Heij, L., Middleton, M. R., Markowetz, F., Grabsch, H. I., Dustin, M. L., & et al. (2019). Immunophenotypes of pancreatic ductal adenocarcinoma: Meta-analysis of transcriptional subtypes.. International Journal of Cancer https://doi.org/10.1002/ijc.32186
Pancreatic ductal adenocarcinoma (PDAC) is the most common malignancy of the pancreas and has one of the highest mortality rates of any cancer type with a 5-year survival rate of <5%. Recent studies of PDAC have provided several transcriptomic classifications based on separate analyses of individual patient cohorts. There is a need to provide a unified transcriptomic PDAC classification driven by therapeutically relevant biologic rationale to inform future treatment strategies. Here, we used an integrative meta-analysis of 353 patients from four different studies to derive a PDAC classification based on immunologic parameters. This consensus clustering approach indicated transcriptomic signatures based on immune infiltrate classified as adaptive, innate and immune-exclusion subtypes. This reveals the existence of microenvironmental interpatient heterogeneity within PDAC and could serve to drive novel therapeutic strategies in PDAC including immune modulation approaches to treating this disease.
T cells, adaptive immunity, innate immunity, pancreatic cancer, subtypes, tumour microenvironment
This study was supported by the NIHR Oxford Biomedical Research Centre. CY is supported by a UK Medical Research Council Research Grant (MR/P02646X/1). MLD is funded by Wellcome Trust grant 100262Z/12/Z. SS is funded by a NIHR Academic Clinical Lecturership.
Cancer Research UK (C14303_do not transfer)
External DOI: https://doi.org/10.1002/ijc.32186
This record's URL: https://www.repository.cam.ac.uk/handle/1810/290730
Attribution-NonCommercial 4.0 International
Licence URL: http://creativecommons.org/licenses/by-nc/4.0/
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