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dc.contributor.authorWood, Valerieen
dc.contributor.authorLock, Antoniaen
dc.contributor.authorHarris, Midorien
dc.contributor.authorRutherford, Kimen
dc.contributor.authorBähler, Jürgen
dc.contributor.authorOliver, Stephenen
dc.date.accessioned2019-04-05T11:14:18Z
dc.date.available2019-04-05T11:14:18Z
dc.date.issued2019-02en
dc.identifier.issn2046-2441
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/291162
dc.description.abstractThe first decade of genome sequencing stimulated an explosion in the characterization of unknown proteins. More recently, the pace of functional discovery has slowed, leaving around 20% of the proteins even in well-studied model organisms without informative descriptions of their biological roles. Remarkably, many uncharacterized proteins are conserved from yeasts to human, suggesting that they contribute to fundamental biological processes. To fully understand biological systems in health and disease, we need to account for every part of the system. Unstudied proteins thus represent a collective blind spot that limits the progress of both basic and applied biosciences. We use a simple yet powerful metric based on Gene Ontology (GO) biological process terms to define characterized and uncharacterized proteins for human, budding yeast, and fission yeast. We then identify a set of conserved but unstudied proteins in S. pombe , and classify them based on a combination of orthogonal attributes determined by large-scale experimental and comparative methods. Finally, we explore possible reasons why these proteins remain neglected and propose courses of action to raise their profile and thereby reap the benefits of completing the catalog of proteins' biological roles.
dc.description.sponsorshipWellcome Trust
dc.format.mediumPrinten
dc.languageengen
dc.publisherThe Royal Society
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectEukaryotic Cellsen
dc.subjectHumansen
dc.subjectSaccharomyces cerevisiaeen
dc.subjectSchizosaccharomycesen
dc.subjectSaccharomyces cerevisiae Proteinsen
dc.subjectSchizosaccharomyces pombe Proteinsen
dc.subjectProteomeen
dc.subjectGene Expression Profilingen
dc.subjectProteomicsen
dc.subjectSpecies Specificityen
dc.subjectGene Ontologyen
dc.titleHidden in plain sight: what remains to be discovered in the eukaryotic proteome?en
dc.typeArticle
prism.issueIdentifier2en
prism.publicationDate2019en
prism.publicationNameOpen biologyen
prism.startingPage180241
prism.volume9en
dc.identifier.doi10.17863/CAM.38344
dcterms.dateAccepted2019-01-13en
rioxxterms.versionofrecord10.1098/rsob.180241en
rioxxterms.versionVoR*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-02en
dc.contributor.orcidWood, Valerie [0000-0001-6330-7526]
dc.contributor.orcidHarris, Midori Akiko [0000-0003-4148-4606]
dc.contributor.orcidRutherford, Kim [0000-0001-6277-726X]
dc.contributor.orcidBähler, Jürg [0000-0003-4036-1532]
dc.contributor.orcidOliver, Stephen [0000-0001-6330-7526]
dc.identifier.eissn2046-2441
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (104967/Z/14/Z)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International