The Evolution of Glioblastoma: A Single Case Study
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Glioblastoma multiforme (GBM) is the most malignant and common primary brain cancer in adults, with a 2.5-year survival of only $~
Moreover, the DNA analysis of the patient showed one shared mutation in high copy number in all of the nine samples: a mutation in EGFR G598V. We hypothesise that subsequent tumours developed from an original clone bearing this mutation. This mutated oncogene is located on an extrachromosomal circular DNA structure known as a double minute (DM), which is found in an estimated 40
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Tavaré, Simon