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dc.contributor.authorFagan, Aisling
dc.contributor.authorFuld, Jonathan
dc.contributor.authorSoon, Elaine
dc.date.accessioned2019-04-17T23:30:08Z
dc.date.available2019-04-17T23:30:08Z
dc.date.issued2017-03-08
dc.identifier.issn1757-790X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/291814
dc.description.abstractLevetiracetam is widely regarded as a benign antiepileptic drug, compared to older antiepileptic medication. We report a case of eosinophilic pneumonia due to levetiracetam use in a non-smoking woman aged 59 years with no previous respiratory history. Our patient presented with exertional breathlessness and marked desaturation on exertion. She displayed 'reverse bat-wing' infiltrates on her chest radiograph and peripheral eosinophilia on a complete blood count. Her symptoms, radiology and peripheral eosinophilia resolved completely with cessation of levetiracetam and a course of prednisolone. This is the first report of isolated eosinophilic pneumonia due to levetiracetam. Other reports of levetiracetam-induced eosinophilia describe drug rash, eosinophilia and systemic symptoms (DRESS syndrome). Detection of pulmonary drug reactions requires a careful drug history and high index of suspicion. Identifying and reporting a causative agent is crucially important, as cessation of the drug is essential for resolution of the syndrome.
dc.format.mediumElectronic
dc.languageeng
dc.publisherBMJ
dc.rightsAll rights reserved
dc.subjectHumans
dc.subjectPulmonary Eosinophilia
dc.subjectPiracetam
dc.subjectPrednisolone
dc.subjectTreatment Outcome
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectLevetiracetam
dc.titleLevetiracetam-induced eosinophilic pneumonia.
dc.typeArticle
prism.publicationDate2017
prism.publicationNameBMJ Case Rep
prism.volume2017
dc.identifier.doi10.17863/CAM.38974
rioxxterms.versionofrecord10.1136/bcr-2016-219121
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-03-08
dc.contributor.orcidFuld, Jonathan [0000-0003-1847-184X]
dc.contributor.orcidSoon, Elaine [0000-0002-5744-5014]
dc.identifier.eissn1757-790X
rioxxterms.typeJournal Article/Review
cam.issuedOnline2017-03-08
rioxxterms.freetoread.startdate2018-03-08


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