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dc.contributor.authorJackson, Rebeccaen
dc.contributor.authorBajada, Claude Jen
dc.contributor.authorLambon Ralph, Matthewen
dc.contributor.authorCloutman, Lauren Len
dc.date.accessioned2019-04-17T23:31:19Z
dc.date.available2019-04-17T23:31:19Z
dc.date.issued2020-01en
dc.identifier.issn1047-3211
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/291841
dc.description.abstractThe functional heterogeneity of the ventromedial prefrontal cortex (vmPFC) suggests it may include distinct functional subregions. To date these have not been well elucidated. Regions with differentiable connectivity (and as a result likely dissociable functions) may be identified using emergent data-driven approaches. However, prior parcellations of the vmPFC have only considered hard splits between distinct regions, although both hard and graded connectivity changes may exist. Here we determine the full pattern of change in structural and functional connectivity across the vmPFC for the first time and extract core distinct regions. Both structural and functional connectivity varied along a dorsomedial to ventrolateral axis from relatively dorsal medial wall regions to relatively lateral basal orbitofrontal cortex. The pattern of connectivity shifted from default mode network to sensorimotor and multimodal semantic connections. This finding extends the classical distinction between primate medial and orbital regions by demonstrating a similar gradient in humans for the first time. Additionally, core distinct regions in the medial wall and orbitofrontal cortex were identified that may show greater correspondence to functional differences than prior hard parcellations. The possible functional roles of the orbitofrontal cortex and medial wall are discussed.
dc.description.sponsorshipThis work was supported by a doctoral prize from the Engineering and Physical Sciences Research Council and a British Academy Postdoctoral Fellowship (pf170068) to RLJ, a studentship from the BBSRC (BB/J014478/1) to CJB, and programme grants from the Medical Research Council (MR/J004146/1 & MR/R023883/1) to MALR.
dc.format.mediumPrinten
dc.languageengen
dc.publisherOxford University Press
dc.rightsAll rights reserved
dc.rights.uri
dc.titleThe Graded Change in Connectivity across the Ventromedial Prefrontal Cortex Reveals Distinct Subregions.en
dc.typeArticle
prism.endingPage180
prism.issueIdentifier1en
prism.publicationDate2020en
prism.publicationNameCerebral cortex (New York, N.Y. : 1991)en
prism.startingPage165
prism.volume30en
dc.identifier.doi10.17863/CAM.39001
dcterms.dateAccepted2019-03-19en
rioxxterms.versionofrecord10.1093/cercor/bhz079en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-01en
dc.contributor.orcidJackson, Rebecca [0000-0001-5339-0266]
dc.contributor.orcidBajada, Claude J [0000-0001-6138-4851]
dc.contributor.orcidLambon Ralph, Matthew [0000-0001-5907-2488]
dc.identifier.eissn1460-2199
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/R023883/1)
cam.orpheus.successThu Jan 30 10:47:57 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-04-26


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