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dc.contributor.authorAydin, Ezra
dc.contributor.authorHolt, Rosemary
dc.contributor.authorChaplin, Daren
dc.contributor.authorHawkes, Rebecca
dc.contributor.authorAllison, Carrie
dc.contributor.authorHackett, Gerald
dc.contributor.authorAustin, Topun
dc.contributor.authorTsompanidis, Alex
dc.contributor.authorGabis, Lidia
dc.contributor.authorZiv, Shimrit Ilana
dc.contributor.authorBaron-Cohen, Simon
dc.date.accessioned2019-05-02T23:30:12Z
dc.date.available2019-05-02T23:30:12Z
dc.date.issued2019-06
dc.identifier.issn0197-3851
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/292236
dc.description.abstractOBJECTIVE: This study measured anogenital distance (AGD) during late second/early third trimester of pregnancy to confirm previous findings that AGD can be measured noninvasively in the fetus using ultrasound and further showed differences in reference ranges between populations. METHOD: Two hundred ten singleton pregnancies were recruited at the Rosie Hospital, Cambridge, UK. A 2D ultrasound was performed between 26 and 30 weeks of pregnancy. AGD was measured from the centre of the anus to the base of the scrotum in males and to the posterior convergence of the fourchette in females. RESULTS: A significant difference in AGD between males and females (P < .0001) was found, replicating previous results with a significant correlation between estimated fetal weight (EFW) and AGD in males only (P = .006). A comparison of AGD using reference data from an Israeli sample (n = 118) and our UK sample (n = 208) showed a significant difference (P < .0001) in both males and females, after controlling for gestational age (GA). CONCLUSION: Our results confirm that AGD measurement in utero using ultrasound is feasible. In addition, there are strong sex differences, consistent with previous suggestions that AGD is influenced by prenatal androgen exposure. AGD lengths differ between the UK and Israel; therefore, population-specific normative values may be required for accurate clinical assessments.
dc.description.sponsorshipMedical Research Council (MRC) Wellcome Trust Autism Research Trust (ART) National Institute for Health Research (NIHR) Templeton World Charitable Foundation.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.rightsAll rights reserved
dc.subjectPerineum
dc.subjectGenitalia
dc.subjectPenis
dc.subjectScrotum
dc.subjectFetus
dc.subjectHumans
dc.subjectFetal Growth Retardation
dc.subjectUltrasonography, Prenatal
dc.subjectBody Weights and Measures
dc.subjectGestational Age
dc.subjectPregnancy
dc.subjectSex Characteristics
dc.subjectAdult
dc.subjectIsrael
dc.subjectAnal Canal
dc.subjectFemale
dc.subjectMale
dc.subjectSex Determination Analysis
dc.titleFetal anogenital distance using ultrasound.
dc.typeArticle
prism.endingPage535
prism.issueIdentifier7
prism.publicationDate2019
prism.publicationNamePrenat Diagn
prism.startingPage527
prism.volume39
dc.identifier.doi10.17863/CAM.39385
dcterms.dateAccepted2019-04-10
rioxxterms.versionofrecord10.1002/pd.5459
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-06
dc.contributor.orcidAydin, Ezra [0000-0003-4845-053X]
dc.contributor.orcidAustin, Topun [0000-0002-8428-8624]
dc.contributor.orcidBaron-Cohen, Simon [0000-0001-9217-2544]
dc.identifier.eissn1097-0223
rioxxterms.typeJournal Article/Review
cam.issuedOnline2019-05-10
cam.orpheus.successThu Jan 30 10:47:07 GMT 2020 - Embargo updated
rioxxterms.freetoread.startdate2020-06-30


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