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dc.contributor.authorAydin, Ezraen
dc.contributor.authorHolt, Rosemaryen
dc.contributor.authorChaplin, Darenen
dc.contributor.authorHawkes, Rebeccaen
dc.contributor.authorAllison, Carrieen
dc.contributor.authorHackett, Geralden
dc.contributor.authorAustin, Topunen
dc.contributor.authorTsompanidis, Alexandrosen
dc.contributor.authorGabis, Lidiaen
dc.contributor.authorZiv, Shimrit Ilanaen
dc.contributor.authorBaron-Cohen, Simonen
dc.date.accessioned2019-05-02T23:30:12Z
dc.date.available2019-05-02T23:30:12Z
dc.date.issued2019-06en
dc.identifier.issn0197-3851
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/292236
dc.description.abstractObjective: This study measured anogenital distance (AGD) during late second/early third trimester of pregnancy to confirm previous findings that AGD can be measured non-invasively in the fetus using ultrasound, and further showed differences in reference ranges between populations. Method: 210 singleton pregnancies were recruited at the Rosie Hospital, Cambridge, UK. A 2D ultrasound was performed between 26-30 weeks pregnancy. AGD was measured from the centre of the anus to the base of the scrotum in males, and to the posterior convergence of the fourchette in females. Results: A significant difference in AGD between males and females (p<.0001) was found, replicating previous results with a significant correlation between estimated fetal weight (EFW) and AGD in males only (p=.006). A comparison of AGD using reference data from an Israeli sample (n=118) and our UK sample (n=208) showed a significant difference (p<.0001) in both males and females, after controlling for gestational age (GA). Conclusion: Our results confirm AGD measurement in utero using ultrasound is feasible. In addition, there are strong sex differences, consistent with previous suggestions that AGD is influenced by prenatal androgen exposure. AGD lengths differ between the UK and Israel, therefore population-specific normative values may be required for accurate clinical assessments.
dc.description.sponsorshipMedical Research Council (MRC) Wellcome Trust Autism Research Trust (ART) National Institute for Health Research (NIHR) Templeton World Charitable Foundation.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherJohn Wiley & Sons Inc.
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectPerineumen
dc.subjectGenitaliaen
dc.subjectPenisen
dc.subjectScrotumen
dc.subjectFetusen
dc.subjectHumansen
dc.subjectFetal Growth Retardationen
dc.subjectUltrasonography, Prenatalen
dc.subjectBody Weights and Measuresen
dc.subjectGestational Ageen
dc.subjectPregnancyen
dc.subjectSex Characteristicsen
dc.subjectAdulten
dc.subjectIsraelen
dc.subjectAnal Canalen
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectSex Determination Analysisen
dc.titleFetal anogenital distance using ultrasound.en
dc.typeArticle
prism.endingPage535
prism.issueIdentifier7en
prism.publicationDate2019en
prism.publicationNamePrenatal diagnosisen
prism.startingPage527
prism.volume39en
dc.identifier.doi10.17863/CAM.39385
dcterms.dateAccepted2019-04-10en
rioxxterms.versionofrecord10.1002/pd.5459en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2019-06en
dc.contributor.orcidAydin, Ezra [0000-0003-4845-053X]
dc.contributor.orcidAllison, Carrie [0000-0003-2272-2090]
dc.contributor.orcidAustin, Topun [0000-0002-8428-8624]
dc.contributor.orcidTsompanidis, Alexandros [0000-0002-7338-6536]
dc.contributor.orcidBaron-Cohen, Simon [0000-0001-9217-2544]
dc.identifier.eissn1097-0223
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successThu Jan 30 10:47:07 GMT 2020 - Embargo updated*
rioxxterms.freetoread.startdate2020-06-30


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