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dc.contributor.authorGu, Zhengying
dc.contributor.authorLiu, Tianqing
dc.contributor.authorTang, Jie
dc.contributor.authorYang, Yannan
dc.contributor.authorSong, Hao
dc.contributor.authorTuong, Zewen K
dc.contributor.authorFu, Jianye
dc.contributor.authorYu, Chengzhong
dc.date.accessioned2019-05-13T23:31:02Z
dc.date.available2019-05-13T23:31:02Z
dc.date.issued2019-04-17
dc.identifier.issn0002-7863
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/292753
dc.description.abstractIron oxide nanoparticles (IONPs) have emerging anticancer applications via polarizing tumor-associated macrophages from tumor-promoting phenotype (M2) to tumor-suppressing phenotype (M1). However, the underlying mechanism and structure-function relationship remain unclear. We report magnetite IONPs are more effective compared to hematite in M1 polarization and tumor suppression. Moreover, magnetite IONPs specifically rely on interferon regulatory factor 5 signaling pathway for M1 polarization and down-regulate M2-assoicated arginase-1. This study provides new understandings and paves the way for designing advanced iron-based anticancer technologies.
dc.description.sponsorshipThe authors acknowledge the support from the Australian Research Council, Australian Microscopy and Microanalysis Research Facil- ity at the Centre for Microscopy and Microanalysis and the Aus- tralian National Fabrication Facility at the University of Queens- land. Z.Y.G acknowledges the Australia Research Training Pro- gram (RTP) Scholarship. Z.K.T. is supported by an Advance Queensland Research Fellowship.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherAmerican Chemical Society (ACS)
dc.rightsAll rights reserved
dc.subjectMacrophages
dc.subjectAnimals
dc.subjectMice
dc.subjectFerric Compounds
dc.subjectLipopolysaccharides
dc.subjectSignal Transduction
dc.subjectMacrophage Activation
dc.subjectPhenotype
dc.subjectNanoparticles
dc.subjectRAW 264.7 Cells
dc.titleMechanism of Iron Oxide-Induced Macrophage Activation: The Impact of Composition and the Underlying Signaling Pathway.
dc.typeArticle
prism.endingPage6126
prism.issueIdentifier15
prism.publicationDate2019
prism.publicationNameJ Am Chem Soc
prism.startingPage6122
prism.volume141
dc.identifier.doi10.17863/CAM.39910
dcterms.dateAccepted2019-04-01
rioxxterms.versionofrecord10.1021/jacs.8b10904
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-04-04
dc.contributor.orcidSong, Hao [0000-0002-6383-0605]
dc.contributor.orcidYu, Chengzhong [0000-0003-3707-0785]
dc.identifier.eissn1520-5126
rioxxterms.typeJournal Article/Review
cam.issuedOnline2019-04-04
cam.orpheus.successThu Jan 30 10:45:30 GMT 2020 - Embargo updated
rioxxterms.freetoread.startdate2020-04-04


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